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Quantitative Assessment of Cortical Auditory-tactile Processing in Children with Disabilities

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Published on: January 29, 2014

Developing a Calibration Method to Minimize Variability in Auditory Evoked Potentials.

Joseph Pinkl^1,2,3, Tao Shen⁴, Jinsai Cheng⁴

¹Department of Research and Development, Gateway Biotechnology Inc., St. Louis, MO, USA. jpinkl@gatewaybiotechnology.com.

Journal of the Association for Research in Otolaryngology : JARO

|March 21, 2025

Summary

This summary is machine-generated.

A new calibration pulse (CalPulse) circuit improves auditory evoked potential (AEP) measurements by reducing amplitude variability. This enhanced calibration accurately detects age-related hearing loss in mice, improving diagnostic sensitivity.

Keywords:

Auditory brainstem response Calibration Cochlear synaptopathy Hearing loss

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A Method for Tracking the Time Evolution of Steady-State Evoked Potentials

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Published on: May 25, 2019

Area of Science:

Neuroscience
Auditory Neuroscience
Biomedical Engineering

Background:

Auditory evoked potentials (AEPs) are crucial for assessing auditory function.
Amplitude variability in AEPs can hinder accurate diagnosis.
A reliable calibration method is needed to improve AEP measurement consistency.

Purpose of the Study:

To develop and validate an electric calibration pulse (CalPulse) circuit for AEP amplitude measurement.
To determine if CalPulse signals serve as a reliable reference for AEP amplitude calibration.
To assess the utility of CalPulse for detecting age-related changes in auditory function.

Main Methods:

Integrated a CalPulse circuit into an AEP recording setup.
Assessed CalPulse signal stability and repeatability in vitro and in vivo in mice.
Used sine wave CalPulse amplitudes to normalize ABR wave-1 amplitudes.
Compared variability of normalized versus raw ABR wave-1 amplitudes over 4 months.

Main Results:

Both square and sine wave CalPulse signals were stable in vitro; sine waves showed better in vivo repeatability.
CalPulse amplitudes positively correlated with ABR wave-1 amplitudes.
Normalization significantly reduced within-subject variability in wave-1 amplitudes.
Normalized amplitudes detected age-related hearing decline at 10 months, unlike uncalibrated amplitudes.

Conclusions:

The developed CalPulse circuit effectively reduces AEP amplitude variability.
CalPulse provides a reliable calibration reference for AEP amplitude measurements.
This method enhances diagnostic sensitivity for auditory function assessment.