Related Experiment Video

Updated: May 21, 2025

Microarray-based Identification of Individual HERV Loci Expression: Application to Biomarker Discovery in Prostate Cancer
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Of HIFs and hERVs: Neoantigen generation in kidney cancer

Nicholas J Salgia1, Nazli Dizman2, Sumanta K Pal3

  • 1Department of Immunology, Roswell Park Comprehensive Cancer Center, Buffalo, NY, USA; Jacobs School of Medicine and Biomedical Sciences, University at Buffalo, Buffalo, NY, USA.

Cancer Cell
|March 21, 2025
PubMed

Insights

Hypoxia-inducible factor 2 alpha (HIF2α) influences the creation of neoantigens in clear cell renal cell carcinoma (ccRCC). This discovery may enhance antitumor immunity and improve responses to immunotherapy for ccRCC patients.

Area of Science:

  • Oncology
  • Immunology
  • Molecular Biology

Background:

  • Clear cell renal cell carcinoma (ccRCC) is a complex cancer.
  • Understanding the tumor microenvironment is crucial for effective treatment.
  • Hypoxia-inducible factors (HIFs) play a significant role in cancer progression.

Purpose of the Study:

  • To investigate the role of HIF activity in neoantigen production in ccRCC.
  • To explore the link between HIF2α and immunogenic elements in ccRCC.
  • To understand the implications for antitumor immunity and immunotherapy.

Main Methods:

  • Analysis of gene expression related to HIFs and neoantigens.
  • Investigating the regulation of human endogenous retroelements (HERs) by HIF2α.
  • Correlating findings with immune response and treatment outcomes.

Main Results:

  • HIF2α was found to regulate the expression of immunogenic HERs in ccRCC.
  • This regulation has direct implications for the generation of neoantigens.
  • The study provides a molecular link between hypoxia and immune evasion.

Conclusions:

  • HIF2α is a key regulator of neoantigen production via HERs in ccRCC.
  • Targeting HIF2α may represent a novel strategy to enhance antitumor immunity.
  • These findings offer insights into improving immunotherapy effectiveness in ccRCC.

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