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Giovanni Occhipinti1, Anthony Salazar-Rodriguez1, Francesco Giannini2

  • 1Hospital Clínic, Cardiovascular Clinic Institute, Institut d'Investigacions Biomèdiques August Pi i Sunyer, University of Barcelona, Barcelona, Spain.

JACC. Case Reports
|March 21, 2025
PubMed

Keywords:
A-Fluxcoronary artery diseasecoronary sinus reductionmicrovascular dysfunction

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The activation of the sympathetic nervous system and the renin-angiotensin-aldosterone system (RAAS) contributes to cardiac remodeling, and inhibiting the RAAS is a pharmacological target in heart failure management. As a result, neurohumoral modulation is a crucial treatment principle for managing heart failure. This approach involves using medications like ACE inhibitors (ACEIs), angiotensin receptor blockers (ARBs), β-blockers, mineralocorticoid receptor antagonists (MRAs), and neutral...
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