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Updated: May 21, 2025
12:40
Cultivation of Heligmosomoides Polygyrus: An Immunomodulatory Nematode Parasite and its Secreted Products
Published on: April 6, 2015
18.2K
Enteric neurons and immune cells shape anti-helminth immunity
Zachary Kerner1, Albana L Kodra2, Daniel Mucida2
1Laboratory of Mucosal Immunology, Rockefeller University, New York, NY, USA.
Trends in Parasitology
|March 21, 2025
Summary
During helminth infection, gut neurons sense immune signals and release CGRP to limit innate lymphoid cell (ILC) activity, revealing a key regulatory pathway for type-2 immunity.
Area of Science:
- Immunology
- Neuroscience
- Gastroenterology
Background:
- Helminth infections trigger type-2 immune responses.
- Innate lymphoid cells (ILCs) are crucial for anti-helminth immunity.
- Gut neurons interact with the immune system.
Purpose of the Study:
- To investigate the communication between enteric neurons and ILCs during helminth infection.
- To elucidate the role of neuronal signaling in regulating type-2 immunity.
Main Methods:
- The study likely involved animal models of helminth infection.
- Analysis of immune cell populations and cytokine production.
- Investigation of neuronal signaling pathways, possibly involving CGRP.
Main Results:
- Innate lymphoid cell-derived IL-13 is detected by gut neurons.
- Gut neurons secrete calcitonin gene-related peptide (CGRP).
- CGRP inhibits ILC2 proliferation and anti-helminth responses.
Conclusions:
- A bidirectional crosstalk exists between enteric neurons and innate lymphoid cells.
- This interaction regulates type-2 immunity during helminth infection.
- Neuronal signaling provides a feedback mechanism to control immune responses.
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