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Identifying and validating immunological biomarkers in obstructive sleep apnea through bioinformatics analysis.
En-Hui Zhou1,2,3, Tian-Jiao Zhou1,2,3, Xiao-Ting Wang1,2,3
1Department of Otorhinolaryngology Head and Neck Surgery, Shanghai Sixth People's Hospital Affiliated to Shanghai Jiao Tong University School of Medicine, No. 600 Yishan Road, Shanghai, 200233, China.
Scientific Reports
|March 22, 2025
Summary
Obstructive sleep apnea (OSA) involves immune system dysfunction. This study identifies key immune-related genes and cells, offering new insights into OSA mechanisms and potential diagnostic markers.
Area of Science:
- Immunology
- Sleep Medicine
- Genetics
Background:
- Obstructive sleep apnea (OSA) is a common disorder linked to immune system dysregulation.
- The specific immune mechanisms and biomarkers in OSA require further elucidation.
Purpose of the Study:
- To identify immune-related genes and biological pathways associated with OSA.
- To explore immune cell involvement and potential biomarkers for OSA diagnosis and management.
Main Methods:
- Analysis of OSA gene expression datasets (GSE38792) and immune-related genes.
- Utilized Gene Ontology (GO), KEGG, and Gene Set Enrichment Analysis (GSEA) for functional enrichment.
- Employed CIBERSORT for immune cell infiltration analysis and RT-qPCR for validation.
Main Results:
- Differentially expressed immune-related genes (DEIRGs) were identified, enriched in immune response regulation and antigen processing.
- Key DEIRGs include IL33, IL10RB, ANGPTL1, and EIF2AK2, with specific immune cells like memory B cells implicated.
- Validation confirmed upregulation of IL33, EIF2AK2, IL10RB, and ANGPTL1 in clinical OSA samples.
Conclusions:
- This study pinpoints crucial immune-related biomarkers and elucidates immunological mechanisms in OSA.
- Findings offer potential avenues for improved OSA diagnosis, mechanistic understanding, and therapeutic strategies.
