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Multifaceted function of B cells in tumorigenesis.
Na Kang1,2, Qinghui Duan1,2, Xin Min1,2
1State Key Laboratory of Membrane Biology, School of Life Sciences, Institute for Immunology, China Ministry of Education Key Laboratory of Protein Sciences, Beijing Key Lab for Immunological Research on Chronic Diseases, Beijing Tsinghua Changgung Hospital, Tsinghua University, Beijing, 100084, China.
Frontiers of Medicine
|March 22, 2025
Summary
B lymphocytes (B cells) have a dual role in cancer, aiding and hindering anti-tumor immunity. Understanding these complex functions is key to improving B cell-based cancer immunotherapy strategies.
Area of Science:
- Immunology
- Oncology
- Cancer Research
Background:
- B lymphocytes (B cells) exhibit paradoxical roles in cancer development and progression.
- B cells can act as anti-tumor allies by recognizing antigens and producing tumor-specific antibodies.
- Conversely, B cells can promote immunosuppression and tumor growth through cytokine secretion and tumor-promoting antibodies.
Purpose of the Study:
- To review the multifaceted functions of B cells in tumorigenesis.
- To summarize current applications of B cells in cancer immunotherapy.
- To explore future directions and challenges in harnessing B cell anti-tumor potential.
Main Methods:
- Literature review of B cell functions in cancer.
- Analysis of B cell-mediated immune responses in tumors.
- Discussion of current and emerging cancer immunotherapy strategies involving B cells.
Main Results:
- B cells possess both tumor-promoting and tumor-eliminating capabilities.
- Immunosuppressive functions of B cells can be exploited by tumors.
- Tumor-associated antigens recognized by B cells offer therapeutic targets.
Conclusions:
- The dual nature of B cells presents both opportunities and challenges for cancer immunotherapy.
- Further research is needed to fully leverage the anti-tumor potential of B cells.
- Targeted manipulation of B cell functions may enhance cancer treatment efficacy.
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