Plasma levels of amino acids and osteoporosis: a cross-sectional study

The role of amino acids (AAs) with bone health is still controversial. We examined the association between AAs and osteoporosis in a cross-sectional study of 135 participants aged 45 years or older from the Second Hospital of Jilin University. Plasma AAs were measured with targeted quantitative methodology. We measured bone mineral density (BMD) with dual energy x-ray absorptiometry, and osteoporosis was defined as a T-score ≤ -2.5. We estimated odds ratios (OR) and corresponding 95% confidence intervals (CIs) for the associations between AAs (per 1 standard deviation increase) with osteoporosis. Approximately 18.5% of participants (n = 25) had osteoporosis. Total (adjusted β = 0.052; P = 0.002) and non-essential AA (adjusted β = 0.064; P = 0.002) levels were associated with femoral neck BMD T-scores. Greater levels of total (adjusted OR: 0.734; 95% CI: 0.655-0.821), essential (adjusted OR: 0.763; 95% CI: 0.623-0.934) and non-essential AAs (adjusted OR: 0.721; 95% CI: 0.629-0.826) were associated with lower odds of osteoporosis. Higher tryptophan (adjusted OR: 0.498; 95% CI: 0.281-0.882), cysteine (adjusted OR: 0.561; 95% CI: 0.321-0.983), glycine (adjusted OR: 0.513; 95% CI: 0.285-0.922), and ornithine levels (adjusted OR: 0.581; 95% CI: 0.345-0.978) were associated with reduced osteoporosis risk. Higher AA levels were associated with higher femoral neck BMD, and lower odds of osteoporosis.