Aggregation-induced emission-based aptasensors for the detection of various targets: Recent progress

The advancement of aptasensors utilizing aggregation-induced emission (AIE) has progressed remarkably in recent years, owing to various unique benefits provided by aggregation-induced emission luminogens (AIEgens) as a novel category of fluorescent substances and aptamers as exceptional recognition components. AIE refers to a photophysical phenomenon identified in certain luminogens that show minimal or absent emission in dilute solutions, yet display considerable emission when in aggregate or solid states. Fluorescent sensing is an effective technique for the detection of various targets; however, many traditional dyes frequently demonstrate an aggregation-caused quenching (ACQ) effect in solid form, which limits their applicability on a larger scale. In contrast, fluorescent probes that leverage AIE characteristics have garnered considerable interest, owing to their elevated fluorescence quantum yields and ease of fabrication. This review discusses the application of various AIEgens in the design of diverse sensitive and selective AIE-based aptasensors for monitoring various targets, with a particular focus on recent advances. The AIE-based aptasensors exploit the supreme affinity of the aptamers to their targets and the remarkable properties of AIEgen, including its photostability and high quantum yield, and the interaction between AIEgen and DNA. The objective is to acquaint researchers with the various categories of materials exhibiting AIE characteristics and their potential applications in the creation of different aptasensors, enabling them to introduce novel kinds of innovative AIEgens and AIE-integrated aptasensors.