Advancing Alzheimer's disease therapy through engineered exosomal Macromolecules.

Area of Science:

• Neuroscience and Pharmacology
• Biotechnology and Drug Delivery

Background:

• Exosomes, as extracellular vesicles (EVs), play a role in the pathophysiology of neurodegenerative disorders (NDDs) like Alzheimer's disease (AD).
• These vesicles can transport both therapeutic and pathogenic molecules, making them a focus of research.

Purpose of the Study:

• To review existing literature on the therapeutic and diagnostic potential of exosomes in Alzheimer's disease.
• To explore the rationale behind using exosomes for drug delivery and early detection of NDDs.

Main Methods:

• Literature review of studies investigating exosome function in NDDs.
• Analysis of exosome characteristics for drug delivery applications.
• Evaluation of exosome utility in disease diagnosis and prediction.

Main Results:

• Exosomes demonstrate potential as natural drug delivery vehicles with reduced immunogenicity.
• They offer efficient medication delivery for Alzheimer's disease with minimal side effects.
• Exosomes are being explored for early diagnosis and prediction of neurodegenerative disorders.

Conclusions:

• Exosomes hold significant therapeutic promise for Alzheimer's disease treatment.
• Their role as diagnostic and predictive tools for NDDs is a promising area of ongoing research.