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SARS-CoV-2 vaccination reduces the risk of thrombotic complications in severe COVID-19
M Ángeles Alonso Fernández1, Carola Bledig2, Madian Manso Álvarez1
1Hospital Universitario del Tajo, Critical Care Department, Universidad Alfonso X El Sabio, Spain.
Objectives:
The aim of this study was to evaluate the association between SARS-CoV-2 vaccination and the occurrence of thrombotic complications in patients admitted to intensive care for severe COVID-19 pneumonia.
Design:
Observational, descriptive, prospective, multicentre study.
Setting:
Intensive care units of five university hospitals.
Patients:
A total of 255 patients admitted to the intensive care unit (ICU) with SARS-CoV-2 pneumonia, confirmed by RT-PCR in throat swab or tracheal aspirate, starting the date the first vaccinated patient against SARS-CoV-2 was admitted in one of the participating ICUs, were included in the analysis.
Main Variables Of Interest:
Vaccination status against SARS-CoV-2 and thrombotic events.
Results:
18.8% of patients had received some form of vaccination. Thrombotic events occurred in 21.2% of patients. Lack of vaccination was associated with thrombotic events (OR 5.024; 95% CI: 1.104-23.123; p = 0.0037) and death (OR 5.161; 95% CI: 1.075-24.787; p = 0.04). ICU mortality was not associated with the occurrence of thrombotic complications.
Conclusions:
In this series of patients, vaccination against SARS-CoV-2 reduced the risk of thrombotic events and mortality in patients with severe COVID-19 admitted to the ICU. Thrombotic complications did not alter ICU mortality.
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