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Updated: May 21, 2025

Inducement and Evaluation of a Murine Model of Experimental Myopia
Published on: January 22, 2019
Causal effects of allergic diseases on the risk of myopia: a two-sample Mendelian randomization study
Ximin Wei1, Weitao Li2, Rong Liu3
1Refractive Center of Ophthalmology, 3201 Hospital, Hanzhong, Shaanxi, China. ximinwei99@outlook.com.
Objective:
Myopia is a common eye disease, and the effect of allergic diseases on myopia is unclear. This study was to explore the causal relationship between allergic diseases and myopia risk through a two-sample Mendelian randomization (MR) analysis.
Materials And Methods:
Genetic variants related to allergic diseases (allergic conjunctivitis, atopic dermatitis, allergic rhinitis, and asthma) and immunoglobulin E and myopia were extracted from the MRC-IEU Open genome-wide association studies (GWAS) project. The results of MR were based on the inverse-variance weighted (IVW) analysis. The odds ratio (OR) and 95% confidence interval (CI) were used to report causal relationships.
Results:
Genetically predicted asthma [IVW: OR = 1.233 (95% CI: 1.043-1.456), P = 0.0140] and higher immunoglobulin E levels [IVW: OR = 1.136 (95% CI: 1.020-1.265), P = 0.0207] increased the risk of myopia. There was no significant causal relationship between allergic conjunctivitis (IVW: P = 0.2916), atopic dermatitis (IVW: P = 0.3168), and allergic rhinitis (IVW: P = 0.8297) and risk of myopia. Further analysis revealed that the causal correlation of immunoglobulin E levels with myopia risk was caused by outliers.
Conclusions:
Genetically predicted asthma increased the risk of myopia.
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