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ORCHESTRA Delphi consensus: clinical management of SARS-CoV-2 infection in people with HIV

Alessandro Tavelli1, Alessandra Vergori2, Antonella Cingolani3

  • 1Icona Foundation, Milan, Italy; National PhD Programme in One Health Approaches to Infectious Diseases and Life Science Research, Department of Public Health, Experimental and Forensic Medicine, University of Pavia, Pavia, Italy.

Clinical Microbiology and Infection : the Official Publication of the European Society of Clinical Microbiology and Infectious Diseases
|March 23, 2025
PubMed

Insights

This study provides expert consensus on managing COVID-19 in people with HIV (PWH), addressing critical care questions. Recommendations cover disease risk, diagnostics, treatments, and prevention strategies for PWH.

Area of Science:

  • Infectious Diseases
  • Public Health
  • Clinical Medicine

Background:

  • The COVID-19 pandemic created a syndemic with people with HIV (PWH), increasing their disease burden.
  • Optimal COVID-19 care strategies for PWH remain unclear after four years of the pandemic.

Purpose of the Study:

  • To develop evidence-based recommendations for managing COVID-19 in PWH.
  • To inform clinicians and policymakers on critical aspects of COVID-19 care for PWH.

Main Methods:

  • A three-round Delphi methodology was employed.
  • A panel of 34 experts in HIV and COVID-19 infections participated.
  • Consensus was sought on 27 questions related to COVID-19 management in PWH.

Main Results:

  • Consensus was achieved on 19 out of 27 items, yielding 18 final statements.
  • Key areas of consensus include COVID-19 risk, diagnostics, antiviral and antibody treatments, corticosteroid use, and prevention.

Conclusions:

  • The study provides guidance for infectious disease physicians treating PWH with COVID-19.
  • These recommendations address gaps where scientific literature is limited or conflicting.
Abstract

Keywords:
COVID-19ConsensusDelphiHIVSARS-CoV-2

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