Jove
Visualize
Contact Us
JoVE
x logofacebook logolinkedin logoyoutube logo
ABOUT JoVE
OverviewLeadershipBlogJoVE Help Center
AUTHORS
Publishing ProcessEditorial BoardScope & PoliciesPeer ReviewFAQSubmit
LIBRARIANS
TestimonialsSubscriptionsAccessResourcesLibrary Advisory BoardFAQ
RESEARCH
JoVE JournalMethods CollectionsJoVE Encyclopedia of ExperimentsArchive
EDUCATION
JoVE CoreJoVE BusinessJoVE Science EducationJoVE Lab ManualFaculty Resource CenterFaculty Site
Terms & Conditions of Use
Privacy Policy
Policies

Related Concept Videos

Glial Cells01:04

Glial Cells

Overview

You might also read

Related Articles

Articles linked to this work by shared authors, journal, and citation graph.

Sort by
Same author

Astrocytes contribute to olanzapine-mediated reversal of Kleefstra Syndrome-associated neurodevelopmental regression.

The Journal of clinical investigation·2026
Same author

GOATEA: gene set enrichment analysis in R with shiny interactive visualizations.

BMC bioinformatics·2026
Same author

Microelectrode array technology for organoids and microphysiological systems.

Trends in biotechnology·2026
Same author

Human adherent cortical organoids in a multi-well format.

eLife·2026
Same author

Influenza A virus infection impairs neuronal activity in human iPSC-derived NGN2 neural co-cultures.

Acta neuropathologica communications·2026
Same author

Non-polio enterovirus infection and electrophysiological changes in human iPSC-derived neural networks.

EBioMedicine·2026

Related Experiment Video

Updated: Jul 12, 2026

Human Neural Organoids for Studying Brain Cancer and Neurodegenerative Diseases
09:36

Human Neural Organoids for Studying Brain Cancer and Neurodegenerative Diseases

Published on: June 28, 2019

9.8K

In vitro models for human neuroglia.

Bas Lendemeijer1, Femke M S de Vrij2

  • 1Department of Psychiatry, Erasmus MC University Medical Center, Rotterdam, The Netherlands; Department of Psychiatry, Columbia University Medical Center, New York, NY, United States.

Handbook of Clinical Neurology
|March 23, 2025
PubMed
Summary

Human neuroglia, including astrocytes, oligodendrocytes, and microglia, are vital nervous system cells. Current in vitro models, enhanced by stem cell technology, allow studying human neuroglia function and development in health and disease.

Keywords:
Disease modelsHumanIn vitro modelsNeurodevelopmentNeurogliaStem cell technology

More Related Videos

A Cell Culture Model for Studying the Role of Neuron-Glia Interactions in Ischemia
11:36

A Cell Culture Model for Studying the Role of Neuron-Glia Interactions in Ischemia

Published on: November 14, 2020

9.3K
Author Spotlight: Establishing Mixed Neuronal and Glial Cell Cultures from Embryonic Mouse Brains to Study Infection and Innate Immunity
07:41

Author Spotlight: Establishing Mixed Neuronal and Glial Cell Cultures from Embryonic Mouse Brains to Study Infection and Innate Immunity

Published on: June 30, 2023

2.6K

Related Experiment Videos

Last Updated: Jul 12, 2026

Human Neural Organoids for Studying Brain Cancer and Neurodegenerative Diseases
09:36

Human Neural Organoids for Studying Brain Cancer and Neurodegenerative Diseases

Published on: June 28, 2019

9.8K
A Cell Culture Model for Studying the Role of Neuron-Glia Interactions in Ischemia
11:36

A Cell Culture Model for Studying the Role of Neuron-Glia Interactions in Ischemia

Published on: November 14, 2020

9.3K
Author Spotlight: Establishing Mixed Neuronal and Glial Cell Cultures from Embryonic Mouse Brains to Study Infection and Innate Immunity
07:41

Author Spotlight: Establishing Mixed Neuronal and Glial Cell Cultures from Embryonic Mouse Brains to Study Infection and Innate Immunity

Published on: June 30, 2023

2.6K

Area of Science:

  • Neuroscience
  • Cell Biology
  • Developmental Biology

Background:

  • Neuroglia are diverse nervous system cells, including astrocytes, oligodendrocytes, microglia (CNS), and Schwann cells, enteric glia (PNS).
  • Human neuroglia exhibit distinct transcriptomic, morphological, and functional characteristics compared to animal models.
  • Studying human neuroglia in vivo is difficult due to tissue inaccessibility.

Purpose of the Study:

  • To provide an overview of current in vitro models for studying human neuroglia.
  • To discuss models for investigating the function and development of human neuroglia in both healthy and diseased states.

Main Methods:

  • Review of established in vitro models using postmortem, postsurgical, or fetal human tissues.
  • Exploration of advancements in human stem cell differentiation techniques for neuroglia modeling.
  • Analysis of pure cell populations and organotypic slice cultures.

Main Results:

  • Traditional methods provided foundational in vitro models of human neuroglia.
  • Stem cell technologies have significantly expanded the capabilities for creating more physiologically relevant models.
  • A variety of models exist to study human neuroglia in vitro.

Conclusions:

  • In vitro models are crucial for overcoming the challenges of studying human neuroglia.
  • Advancements in stem cell differentiation offer powerful tools for modeling human neuroglia in health and disease.
  • Continued development of these models is essential for understanding neuroglial roles in the nervous system.