Peptides on patrol: Carrier systems for targeted delivery
Vivek P Chavda1, Joanna Bojarska2
1Department of Pharmaceutics and Pharmaceutical Technology, L. M. College of Pharmacy, Ahmedabad, Gujarat, India.
Progress in Molecular Biology and Translational Science
|March 23, 2025
Summary
Peptide therapeutics offer broad applications for various diseases by utilizing advanced carrier molecules for targeted delivery. This research explores nanocarriers for enhanced peptide drug delivery and therapeutic outcomes.
Area of Science:
- Biotechnology and Pharmaceutical Sciences
- Nanomedicine and Drug Delivery Systems
Background:
- Peptides, small protein units, are crucial in cellular signal transduction.
- They possess diverse therapeutic potential for respiratory, inflammatory, oncologic, metabolic, and neurological disorders.
Purpose of the Study:
- To explore advanced peptide delivery systems using nanocarriers.
- To detail applications in treating various diseases and different delivery routes.
- To discuss current limitations and future prospects in peptide therapeutics.
Main Methods:
- Utilizing carrier molecules such as liposomes, micelles, and polymeric nanoparticles.
- Employing inorganic materials for peptide encapsulation and delivery.
- Investigating targeted and site-specific delivery strategies.
Main Results:
- Demonstrated the efficacy of nanocarriers in enhancing peptide drug delivery.
- Highlighted the role of different nanocarriers and drug molecules in therapeutic outcomes.
- Provided a comprehensive overview of peptide applications across multiple disease areas.
Conclusions:
- Nanocarrier-mediated delivery significantly improves peptide therapeutic efficacy.
- Targeted delivery systems are key to overcoming challenges in peptide drug development.
- Further research into nanocarriers promises expanded therapeutic applications for peptides.
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