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Updated: May 20, 2025

Protocol for the Synthesis of Ortho-trifluoromethoxylated Aniline Derivatives
Published on: January 19, 2016
Cobalt-Catalyzed Enantioselective Hydrotrifluoromethoxylation of Aromatic Alkenes
Yafeng Si1, Yuntao Liu1, Fan Zhou2
1State Key Laboratory and Institute of Elemento-Organic Chemistry, Frontiers Science Center for New Organic Matter, College of Chemistry, Nankai University, Tianjin, 300071, China.
Abstract:
The construction of optically pure benzyl trifluoromethoxy (OCF3) compounds continues to present challenges due to limited enantioselectivity-control or the necessity for OCF3-containing substrates in the only two previous reports. Herein, we have developed a salen-Co-catalyzed enantioselective hydrotrifluoromethoxylation reaction involving aromatic alkenes and trifluoromethyl arylsulfonate (TFMS). This method effectively produces a range of chiral benzyl trifluoromethoxy compounds with enantiomeric excesses ranging from 75% to 99%.
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