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The Multiple Sclerosis Performance Test MSPT: An iPad-Based Disability Assessment Tool

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Is there a threshold or dose-response association between physical activity and cognitive function in multiple

Brenda Jeng¹, Gary R Cutter², Robert W Motl¹

¹Department of Kinesiology and Nutrition, University of Illinois Chicago, Chicago, IL, USA.

Journal of the International Neuropsychological Society : JINS

|March 24, 2025

Summary

Increasing daily steps may improve cognitive function in multiple sclerosis (MS). A linear relationship was found between steps per day and cognitive test scores, suggesting benefits across all activity levels.

Keywords:

Multiple sclerosis cognition exercise

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Area of Science:

Neuroscience
Rehabilitation Medicine
Clinical Neurology

Background:

Cognitive impairment is a significant challenge in multiple sclerosis (MS), impacting daily life and disease management.
Physical activity, particularly daily step count, has shown potential links to cognitive health in MS patients.

Purpose of the Study:

To investigate if a specific daily step threshold exists for avoiding cognitive impairment in MS.
To determine if there is a dose-response relationship between daily steps and cognitive function in individuals with MS.

Main Methods:

358 participants with MS completed cognitive tests (SDMT, CVLT-II) and wore accelerometers for 7 days to measure steps/day.
Demographic and clinical data, including MS type and disability status, were collected.

Main Results:

No specific steps/day threshold was identified for absence of cognitive impairment on SDMT or CVLT-II.
Regression analyses revealed significant linear relationships between steps/day and cognitive scores on both SDMT and CVLT-II.

Conclusions:

A linear association exists between daily steps and cognitive function in MS, indicating that higher physical activity levels may enhance cognitive performance.
Encouraging increased daily steps for individuals with MS, regardless of their current activity level, could be a beneficial strategy for cognitive health.