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Reading Performance in Geographic Atrophy: Comparison of Different Reading Speed Measures for Capturing Longitudinal
Zhichao Wu1,2, Verena Steffen3, Will Harris3
1Centre for Eye Research Australia, Royal Victorian Eye and Ear Hospital, East Melbourne, Australia.
Ophthalmology Science
|March 24, 2025
Summary
The Reading Accessibility Index (ACC) and mean reading speed of the 3 fastest sentences (RS2) better capture vision changes in geographic atrophy (GA) than other measures. These methods are recommended for future clinical trials evaluating GA progression.
Area of Science:
- Ophthalmology
- Visual Function Assessment
- Age-Related Macular Degeneration Research
Background:
- Geographic atrophy (GA) is a severe form of age-related macular degeneration (AMD) leading to progressive vision loss.
- Accurate measurement of longitudinal visual function changes is crucial for evaluating treatment efficacy in GA.
- Current reading speed measures may vary in their sensitivity to detect subtle functional declines in GA.
Purpose of the Study:
- To compare the effectiveness of four different reading speed measures in capturing longitudinal visual function changes in individuals with GA.
- To identify the most reliable reading speed metrics for use in clinical trials and research studies involving GA.
Main Methods:
- Analysis of data from two Phase III clinical trials (Chroma and Spectri) involving 940 participants with bilateral GA.
- Monocular reading speed was assessed using the Minnesota Low-Vision Reading Test (MNRead).
- Four reading speed measures were derived: RS1 (fastest sentence), RS2 (mean of 3 fastest sentences), RS3 (sentences larger than critical print size), and ACC (Reading Accessibility Index - mean of 10 largest print sizes).
Main Results:
- All four reading speed measures demonstrated a significant decline over 96 weeks.
- The Reading Accessibility Index (ACC) and RS2 showed lower coefficients of variation (CV) compared to RS1 and RS3, indicating better performance in capturing longitudinal changes.
- Weak negative correlations were observed between changes in reading speed measures and GA area, suggesting limited association with GA growth.
Conclusions:
- The Reading Accessibility Index (ACC) and RS2 are superior measures for detecting progressive functional decline in eyes with GA compared to RS1 and RS3.
- These preferred measures (ACC and RS2) are recommended for future clinical trials and studies assessing GA.
- While reading speed declines progressively in GA, its correlation with GA growth is weak.
Keywords:
Age-related macular degenerationGeographic atrophyReading speedVisual acuityVisual functionMore Related Videos
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