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Updated: May 20, 2025

Preparation of N-2-alkoxyvinylsulfonamides from N-tosyl-1,2,3-triazoles and Subsequent Conversion to Substituted Phthalans and Phenethylamines
Published on: January 3, 2018
A simple protocol for stereoselective construction of novel β-sulfanyl vinyl sulfonyl fluorides
Monday Peter Ajisafe1, Heba H Mohamedy1, Eman Fayad2
1School of Materials Science and Engineering, Wuhan University of Technology, Wuhan 430070, China. qinhuali@whut.edu.cn.
Abstract:
The addition of thiols to 2-bromoprop-2-ene-1-sulfonyl fluoride (BPESF) in the presence of an organic base has been successfully employed for the synthesis of highly functionalized sulfanyl vinyl sulfonyl fluorides. This reaction features a broad substrate scope, mild reaction conditions, high atom economy, good to excellent isolated yields of up to 100%, and remarkable stereoselectivity, making it valuable for applications in chemical biology and medicinal chemistry. Further product diversification resulted in the construction of enaminyl sulfonyl fluorides.
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