Progress of silk fibroin biomaterial use in oral tissue regeneration engineering

The field of tissue engineering has introduced novel prospects for the regeneration of oral tissues, wherein stent materials assume a pivotal role and have garnered increasing attention. As a natural protein with good biocompatibility and adjustable biodegradability, an increasing number of studies focus on the uses of silk fibroin (SF) biomaterials for medical tissue regeneration engineering. Solid evidence has been found for using SF biomaterials in various oral tissue regeneration fields, from endodontics and periodontics to regenerating the maxillofacial bone. In order to provide researchers with a systematic understanding of the application of SF biomaterials to oral tissue regeneration, the present work reviews in detail the common forms of SF biomaterials for oral tissue regeneration as well as their preparation methods. In addition, the common additives used in the corresponding materials are introduced.