A novel indicator of all-cause mortality in acute coronary syndrome: the CALLY index
Barış Güven1,2, Muhammed Furkan Deniz3, Neziha Aybüke Geylan4
1Department of Cardiology, Idil State Hospital, Sirnak, Turkey.
Insights
The C-reactive protein-albumin-lymphocyte (CALLY) index effectively predicts mortality in acute coronary syndrome (ACS) patients post-primary percutaneous coronary intervention (pPCI). A high CALLY index indicates better survival outcomes, establishing it as a novel prognostic tool.
Area of Science:
- Cardiology
- Biomarkers
- Prognostics
Background:
- Acute coronary syndrome (ACS) poses a significant mortality risk.
- Effective prognostic markers are crucial for managing ACS patients undergoing revascularization.
Purpose of the Study:
- To evaluate the prognostic significance of the C-reactive protein-albumin-lymphocyte (CALLY) index.
- To assess the CALLY index's ability to predict all-cause mortality in ACS patients after primary percutaneous coronary intervention (pPCI).
Main Methods:
- Retrospective analysis of 505 ACS patients who underwent pPCI.
- Calculation of the CALLY index and five other prognostic scores.
- Median follow-up of 40 months with all-cause mortality as the primary endpoint.
Main Results:
- The CALLY index independently predicted all-cause mortality (p < 0.001).
- The CALLY index demonstrated superior predictive ability compared to other scores (AUC analysis).
- Patients with a high CALLY index had significantly better survival rates (log-rank: p < 0.001).
Conclusions:
- The CALLY index serves as a novel and effective prognostic score.
- It can be utilized to predict all-cause mortality in ACS patients following pPCI.
Aims:
This study aimed to identify the prognostic significance of the C-reactive protein-albumin-lymphocyte (CALLY) index for predicting all-cause mortality in acute coronary syndrome (ACS) patients who have undergone primary percutaneous coronary intervention (pPCI) for revascularization.
Materials And Methods:
505 patients who presented with ACS and underwent pPCI were retrospectively included in this single center study. CALLY index and other five prognostic scores were calculated. The median follow-up was 40 months. All-cause mortality was defined as the primary endpoint.
Results:
The median age of the patients was 59 years, 23.4% were female. The CALLY index was categorized into low (<0.7) and high (≥0.7). Age (p = 0.038), concomitant atrial fibrillation (p = 0.023), previous CABG (p = 0.001), ACE-I/ARB/ARNI use (p = 0.015), diuretic use (p = 0.021), and a low-CALLY index (p < 0.001) were identified as independent predictors of all-cause mortality in multivariate cox regression analysis. When compared to other prognostic scores according to AUC in ROC analysis, the CALLY index demonstrated the best ability to predict all-cause mortality. Additionally, patients with a high-CALLY index exhibited significantly better survival outcomes compared to those with a low-CALLY index (log-rank:p < 0.001).
Conclusions:
CALLY index can be utilized as a novel prognostic score for predicting all-cause mortality in ACS patients who have undergone pPCI.
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