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Updated: May 20, 2025

Reduced Itraconazole Concentration and Durations Are Successful in Treating Batrachochytrium dendrobatidis Infection in Amphibians
Published on: March 14, 2014
[Life-threatening cardiotoxicity with rifampicin, fucidic acid, and itraconazole]
Nanna Reiter1,2, Julie Bjerre Tarp3, Hasse Møller-Sørensen4
1Anæstesiologisk Afdeling Z, Københavns Universitetshospital - Bispebjerg og Frederiksberg Hospital.
Abstract:
We describe in this case review of life-threatening cardiotoxicity and the need for ECMO treatment following rifampicin, fusidic acid, and itraconazole intake in a previously healthy 19-year-old rifampicin-naive man. The pronounced cardiotoxicity, despite a relatively low dose of rifampicin (9 g), was due to the concurrent intake of itraconazole and fusidic acid, which inhibit the elimination of rifampicin. This case illustrates the importance of considering drug interactions in unforeseen clinical scenarios and the possibility of bridging with ECMO to organ recovery in cases of life-threatening poisoning.
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