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Updated: May 20, 2025

Anti-Nuclear Antibody Screening Using HEp-2 Cells
Published on: June 23, 2014
[Anti-Sjögren's syndrome type A-autoantibodies and pregnancy]
Camilla Lassen Dreyer1, Jens Fuglsang2, Henrik Kjærulf Jensen3,4
1Institut for Biomedicin, Aarhus Universitet.
Abstract:
Anti-Sjögren's syndrome type A (SSA)-autoantibodies are present in ½-1% of the population and associated with neonatal lupus erythematosus (NLE), of which congenital atrioventricular (AV) block is the most severe manifestation. The aim of this review is to map the road for an anti-SSA-autoantibody-positive woman from wish to conceive until birth, and beyond. With proper care, it is possible to reduce both the risk of NLE and AV-block, and today children born with NLE and AV-block can lead an almost normal life. It is vital that all doctors know of the autoantibody, treatment, and possible outcome.
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