Jove
Visualize
Contact Us
JoVE
x logofacebook logolinkedin logoyoutube logo
ABOUT JoVE
OverviewLeadershipBlogJoVE Help Center
AUTHORS
Publishing ProcessEditorial BoardScope & PoliciesPeer ReviewFAQSubmit
LIBRARIANS
TestimonialsSubscriptionsAccessResourcesLibrary Advisory BoardFAQ
RESEARCH
JoVE JournalMethods CollectionsJoVE Encyclopedia of ExperimentsArchive
EDUCATION
JoVE CoreJoVE BusinessJoVE Science EducationJoVE Lab ManualFaculty Resource CenterFaculty Site
Terms & Conditions of Use
Privacy Policy
Policies

Related Concept Videos

Synthetic Biology02:55

Synthetic Biology

4.7K
Synthetic biology is an interdisciplinary science that involves using principles from disciplines such as engineering, molecular biology, cell biology, and systems biology. It involves remodeling existing organisms from nature or constructing completely new synthetic organisms for applications such as protein or enzyme production, bioremediation, value-added macromolecule production, and the addition of desirable traits to crops, to name a few.
Golden rice
Golden rice is a genetically modified...
4.7K

You might also read

Related Articles

Articles linked to this work by shared authors, journal, and citation graph.

Sort by
Same author

Total synthesis of the proposed menominin A and its stereoisomers: identification of a highly potent isomer (1a) against RM-1 prostate cancer cells.

Molecular diversity·2026
Same author

A system of paired polyether epoxide hydrolases enables a mouldable enzyme for consecutive ring cyclization cascades.

Nature chemistry·2026
Same author

Unified Access to Rearranged Steroids via Controlled B-Ring Remodeling of Ergosterol.

The Journal of organic chemistry·2026
Same author

Total Synthesis of Chrysosporazines B and C.

Organic letters·2026
Same author

Divergent Total Syntheses of (-)-Galanthamine, (-)-Narwedine, (-)-Lycoraminone and (-)-Lycoramine, and Formal Syntheses of (-)-Morphine and (-)-Codeine.

Organic letters·2025
Same author

Total Synthesis and Biological Evaluation of Asterriquinol D Dimethyl Ether, Candidusin D, Kumbicins A-B, and Petromurins C-D as α-Glucosidase Inhibitors.

The Journal of organic chemistry·2025

Related Experiment Video

Updated: May 20, 2025

Synthesis of pH Dependent Pyrazole, Imidazole, and Isoindolone Dipyrrinone Fluorophores using a Claisen-Schmidt Condensation Approach
14:11

Synthesis of pH Dependent Pyrazole, Imidazole, and Isoindolone Dipyrrinone Fluorophores using a Claisen-Schmidt Condensation Approach

Published on: June 10, 2021

6.0K

Second-Generation Synthesis of Psymberin.

Jie Yu1,2, Jia-Lei Yan1,2, Fusong Wu1

  • 1State Key Laboratory of Chemical Oncogenomics, Peking University Shenzhen Graduate School, Xili, Nanshan District, Shenzhen 518055, China.

Organic Letters
|March 24, 2025
PubMed
Summary
This summary is machine-generated.

A new synthesis of psymberin offers significant improvements. This second-generation route is shorter and more efficient, increasing the overall yield for this complex molecule.

More Related Videos

Synthetic Methodology for Asymmetric Ferrocene Derived Bio-conjugate Systems via Solid Phase Resin-based Methodology
07:07

Synthetic Methodology for Asymmetric Ferrocene Derived Bio-conjugate Systems via Solid Phase Resin-based Methodology

Published on: March 12, 2015

9.6K
Synthesis of a Borylated Ibuprofen Derivative Through Suzuki Cross-Coupling and Alkene Boracarboxylation Reactions
08:56

Synthesis of a Borylated Ibuprofen Derivative Through Suzuki Cross-Coupling and Alkene Boracarboxylation Reactions

Published on: November 30, 2022

2.6K

Related Experiment Videos

Last Updated: May 20, 2025

Synthesis of pH Dependent Pyrazole, Imidazole, and Isoindolone Dipyrrinone Fluorophores using a Claisen-Schmidt Condensation Approach
14:11

Synthesis of pH Dependent Pyrazole, Imidazole, and Isoindolone Dipyrrinone Fluorophores using a Claisen-Schmidt Condensation Approach

Published on: June 10, 2021

6.0K
Synthetic Methodology for Asymmetric Ferrocene Derived Bio-conjugate Systems via Solid Phase Resin-based Methodology
07:07

Synthetic Methodology for Asymmetric Ferrocene Derived Bio-conjugate Systems via Solid Phase Resin-based Methodology

Published on: March 12, 2015

9.6K
Synthesis of a Borylated Ibuprofen Derivative Through Suzuki Cross-Coupling and Alkene Boracarboxylation Reactions
08:56

Synthesis of a Borylated Ibuprofen Derivative Through Suzuki Cross-Coupling and Alkene Boracarboxylation Reactions

Published on: November 30, 2022

2.6K

Area of Science:

  • Organic Chemistry
  • Synthetic Chemistry

Background:

  • Psymberin is a complex natural product with potential biological activities.
  • Previous syntheses of psymberin have been lengthy and low-yielding.

Purpose of the Study:

  • To develop a more efficient and practical second-generation formal synthesis of psymberin.
  • To optimize key transformations for improved yield and reduced step count.

Main Methods:

  • Utilized a challenging Heck reaction to couple a sterically demanding aryl group with a terminal alkene.
  • Employed Palladium-mediated cyclization for the construction of the isocoumarin core.
  • Developed an improved route from the 2,6-trans-tetrahydropyran fragment to De Brabander's advanced intermediate.

Main Results:

  • The revised synthesis is seven steps shorter than the previous route.
  • Overall yield increased from 5.9% to 9.3%.
  • Demonstrated robustness of the Heck reaction with sterically hindered substrates.

Conclusions:

  • The developed second-generation synthesis represents a significant advancement in psymberin preparation.
  • The optimized route offers enhanced practicality and efficiency.
  • This methodology holds potential for the synthesis of psymberin analogs.