Dialkylation of Alkenes to Fluorinated δ-Lactams Enabled by Nickel-Electron-Shuttle Catalysis
Sunfeng Ye1, Bangkui Yu1, Hanmin Huang1
1State Key Laboratory of Precision and Intelligent Chemistry, Department of Chemistry, University of Science and Technology of China, Hefei, 230026, P. R. China.
Abstract:
The δ-lactam motif is a privileged pharmacophore in drug design and development. While these biologically relevant molecules could be assembled through two-component cyclization, a modular approach to constructing these structures via a multicomponent reaction with unactivated alkenes as starting materials is rare. Herein, we report a tandem reaction that integrates alkene-dialkylation with radical-involved ring-opening and cyclization under a single metal-electron-shuttle catalysis, which represents the most expeditious access to fluorinated δ-lactams from unactivated simple alkenes.
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