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The cross-talk between NRF2 and apoptosis in cancer

Elmira Aboutalebi Vand Beilankouhi1, Bahareh Yousefi2, Niloofar Sadat Hadian3

  • 1Department of Animal Biology, Faculty of Natural Science, University of Tabriz, Tabriz, Iran.

Medical Molecular Morphology
|March 24, 2025
PubMed

Insights

This study explores the connection between the NRF2 pathway and apoptosis in cancer. Understanding this relationship is key to developing new cancer prevention and treatment strategies.

Area of Science:

  • Oncology
  • Molecular Biology
  • Cell Death Research

Background:

  • Cancer's complexity involves genetic and environmental factors.
  • NRF2 (Nuclear factor erythroid 2-related factor 2) regulates antioxidant and cellular protective genes.
  • Apoptosis, or programmed cell death, is crucial in cell signaling and is mediated by caspases.

Purpose of the Study:

  • To investigate the intricate relationship between the NRF2 pathway and apoptosis in the context of cancer.
  • To elucidate how the interplay between NRF2 and apoptosis influences cancer development and progression.

Main Methods:

  • The study involved analyzing the molecular mechanisms linking NRF2 signaling and apoptotic pathways.
  • Investigated the regulation of NRF2 activity by the Keap1-Cul3-Rbx1 axis.
  • Examined the role of caspases in apoptosis.

Main Results:

  • Findings indicate a significant association between NRF2 activity and apoptosis regulation in cancer cells.
  • Disruptions in the NRF2 pathway were observed to impact apoptotic signaling.
  • The Keap1-Cul3-Rbx1 complex's role in modulating NRF2 was highlighted in relation to cell death.

Conclusions:

  • The NRF2 pathway is closely interconnected with apoptosis, influencing cancer's trajectory.
  • Targeting the NRF2-apoptosis axis presents a potential therapeutic avenue for cancer intervention.
  • Further research into this crosstalk is essential for advancing cancer treatment.
Keywords:
ApoptosisBreast cancerCaspaseNRF2

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