Related Experiment Video
Updated: May 20, 2025
09:33
Quantitative 3D In Silico Modeling q3DISM of Cerebral Amyloid-beta Phagocytosis in Rodent Models of Alzheimer's Disease
Published on: December 26, 2016
7.9K
Deciphering T Cell Dynamics in Alzheimer's Disease Pathogenesis: Insights and Implications
Qiqi Yang1, Yunjie Qiu1, Junjun Ni1
1School of Life Science, Beijing Institute of Technology, Beijing, 100081, China.
Current Neuropharmacology
|March 25, 2025
Summary
T cells play a key role in Alzheimer's disease (AD) neuroinflammation. Aberrant T cell activation contributes to AD pathogenesis, suggesting T cell-based therapies may offer new treatment avenues.
Area of Science:
- Neuroimmunology
- Neuroinflammation
- Alzheimer's Disease Pathogenesis
Background:
- Neuroinflammation is central to Alzheimer's disease (AD) development.
- T lymphocytes critically influence the interplay between the peripheral immune system and the central nervous system (CNS).
- Aberrant T cell activation in early neuroinflammation exacerbates disease by interacting with glial cells and releasing pro-inflammatory cytokines.
Purpose of the Study:
- To review the current understanding of T cell involvement in AD pathology.
- To elucidate the mechanisms by which T cells contribute to AD pathogenesis.
- To explore T cell-based therapeutic strategies for AD.
Main Methods:
- Comprehensive literature review synthesizing existing research on T cells in AD.
- Analysis of T cell interactions with microglia and their role in tau pathology.
- Examination of the influence of gut microbiota on T cell-mediated neuroinflammation.
Main Results:
- T cell activation and brain infiltration are observed in AD.
- T cells interact with microglia, influencing neuroinflammation and tau pathology.
- Gut microbiota composition impacts T cell responses relevant to AD.
Conclusions:
- T cells are significant contributors to AD pathogenesis through neuroinflammatory mechanisms.
- Understanding T cell roles offers insights into AD pathophysiology.
- T cell-based therapies show promise for future AD treatment.
Related Concept Videos
01:26Alzheimer's Disease: Overview
399
Alzheimer's Disease (AD) is a continually advancing neurodegenerative disorder, distinguished by escalating memory loss, cognitive dysfunction, and dementia. The disease unfolds in three stages: preclinical, mild cognitive impairment (MCI), and dementia. Its onset is insidious, and the progression gradual, with the cause not well explained by other disorders.
The clinical diagnosis of AD hinges on the presence of memory and other cognitive impairments. Biomarkers, such as changes in Aβ...
The clinical diagnosis of AD hinges on the presence of memory and other cognitive impairments. Biomarkers, such as changes in Aβ...
399
01:22Alzheimer's Disease: Treatment
137
Alzheimer's Disease (AD), a neurodegenerative disorder, is pathologically identified by amyloid plaques and neurofibrillary tangles composed of tau protein. AD pharmacotherapy aims to manage cognitive symptoms, delay disease progression, and treat behavioral symptoms. The treatment is primarily symptomatic and palliative, with no definitive disease-modifying therapy available. Cholinesterase inhibitors, including donepezil (Aricept), rivastigmine (Exelon), and galantamine (Razadyne), are...
137
03:03Amyloid Fibrils
9.1K
Amyloid fibrils are aggregates of misfolded proteins. Under most circumstances, misfolded proteins are either refolded by chaperone proteins or degraded by the proteasome. However, in the case of a mutation or a disease, these proteins can accumulate to form large clusters and often further assemble to form elongated fibers, called fibrils.
Amyloid deposits were observed as early as 1639 in the liver and the spleen. In 1854, Rudolph Virchow performed iodine staining,...
Amyloid deposits were observed as early as 1639 in the liver and the spleen. In 1854, Rudolph Virchow performed iodine staining,...
9.1K
01:30Dementia
78
Dementia is a collective term for cognitive disorders primarily affecting memory, thinking, and reasoning. It is not a specific disease but a syndrome, with Alzheimer's disease being the most common cause, accounting for approximately 60-80% of cases. Other types include vascular dementia, Lewy body dementia, and frontotemporal dementia. Dementia affects millions worldwide, particularly older adults, though it is not a normal part of aging.
The progression of dementia is generally gradual....
The progression of dementia is generally gradual....
78