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Updated: May 20, 2025

Immunoglobulin Gene Sequence Analysis In Chronic Lymphocytic Leukemia: From Patient Material To Sequence Interpretation
Published on: November 26, 2018
Burkitt lymphoma in patients with chronic lymphocytic leukemia and other indolent B-cell lymphoid malignancies
Tadeusz Robak1,2, Agnieszka Pluta1,3, Pawel Robak1
1Department of Hematology, Medical University of Lodz, Lodz, Poland.
Abstract:
The most common form of Richter transformation, observed in 90-95% of patients, is the transformation of chronic lymphocytic leukemia (CLL) into diffuse large B-cell lymphoma (DLBCL). CLL has also been found to transform into Hodgkin lymphoma, prolymphocytic leukemia, and, in extremely rare cases, into other hematological malignancies, including Burkitt lymphoma (BL). This manuscript discusses a case of CLL transforming into BL and reviews a rare collection of cases of Burkitt lymphoma or Burkitt-like lymphoma associated with CLL,B-cell prolymphocytic leukemia, mantle cell lymphoma, follicular lymphoma, lymphoplasmacytic lymphoma and splenic marginal zone lymphoma. It covers the pathogenesis, prognosis, clinical characteristics, and treatment outcomes of Burkitt transformation in CLL and other indolent B-cell lymphoid malignancies patients. A comprehensive search was conducted using PubMed, Web of Science, and Google Scholar for articles published between January 1980 and December 2024 on chronic lymphocytic leukemia, Burkitt lymphoma, indolent lymphoma, mantle cell lymphoma, follicular lymphoma, marginal zone lymphoma, 8q24/MYC rearrangement, Epstein-Barr virus-positive lymphoma, and translocation t(8;14)(q24;q32). Additional relevant publications were identified by reviewing the references cited in the selected articles.
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