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Notch Signaling Pathway Interfering as a Possible Asthma Treatment: A Narrative Review
Jingya Wang1,2, Kang Yan3, Leilei Ma1,4
1College of Traditional Chinese Medicine, North China University of Technology, Tangshan, Hebei, People's Republic of China.
Abstract:
Asthma is a respiratory disease common among all age groups, and there is currently no cure that can be applied, as the patients react differently to the available treatments. Recent studies have shown that the Notch signaling pathway can regulate the dynamic balance between Th1 and Th2 cells, inhibit airway inflammation, reduce airway hyperresponsiveness and remodeling, and promote mesenchymal stem cell (MSCs) homing. This study conducted a comprehensive search of multiple large databases and provided a narrative review of the role of the Notch signaling pathway in asthma.
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