Improving patient understanding of GEP test results (IMPARTER4): an RCT

Area of Science:

• Oncology
• Genomics
• Patient Education

Background:

• Explaining gene expression profiling (GEP) test results to patients presents communication challenges.
• Oestrogen receptor positive (ER+) early-stage breast cancer patients often require GEP tests like Oncotype DX and Prosigna.

Purpose of the Study:

• To evaluate the effectiveness of short educational films in improving patient knowledge and decision-making regarding GEP test results.
• To assess the impact of films on patient understanding of recurrence risk and treatment options.

Main Methods:

• A randomized study involving 230 patients awaiting GEP results.
• Group A received standard information; Group B received standard information plus two 8-minute films.
• Pre- and post-consultation questionnaires and interviews assessed knowledge, anxiety, and decision-making.

Main Results:

• Patients receiving films (Group B) demonstrated significantly higher knowledge scores compared to standard information alone.
• Most treatment decisions aligned with recurrence risk thresholds, though higher anxiety correlated with less statistically "rational" choices.
• Clinicians noted more complex questions from the standard information group.

Conclusions:

• Integrating short educational films significantly enhances patient comprehension of GEP test results.
• Improved knowledge supports more informed treatment decisions for early-stage ER+ breast cancer patients.