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Stem Cell-Derived Viral Ag-Specific T Lymphocytes Suppress HBV Replication in Mice
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Extrathymic CD8 and CD4 Double Positive T Cells Presenting Vigorous HBV-Specific Responses Accelerate HBV Clearance

Zhong Fang1,2, Cong Wang3, Chen-Lu Huang1

  • 1Liver Cancer Institute of Zhongshan Hospital and Key Laboratory of Carcinogenesis and Cancer Invasion (Ministry of Education), Fudan University, Shanghai, China.

Journal of Medical Virology
|March 25, 2025
PubMed
Summary

Extrathymic CD4 and CD8 double positive T (DPT) cells increase during acute Hepatitis B virus (HBV) infection. These DPT cells clear HBV by killing infected cells and may offer a new strategy for treating chronic HBV.

Keywords:
HBV clearanceHBV‐specific responsedouble positive T cellshepatitis B virus

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