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Surgical versus Nonsurgical Treatment for Cervical Radiculopathy
Mirad Taso1,2, Jon Håvard Sommernes2,3, Jarle Sundseth3
1Department of Physical Medicine and Rehabilitation, Oslo University Hospital.
NEJM Evidence
|March 25, 2025
Summary
Surgery improved outcomes for cervical radiculopathy caused by disc herniation, but not spondylosis. This randomized trial compared surgical versus nonsurgical treatments for disabling arm pain.
Area of Science:
- Neurosurgery
- Orthopedics
- Physical Medicine and Rehabilitation
Background:
- Cervical radiculopathy, often caused by disc herniation or spondylosis, presents a treatment challenge.
- Limited comparative trials exist for surgical versus nonsurgical interventions.
Purpose of the Study:
- To compare the efficacy of surgical versus nonsurgical treatments for cervical radiculopathy.
- To evaluate outcomes based on the cause of radiculopathy: disc herniation or spondylosis.
Main Methods:
- Two randomized clinical trials involving 180 patients with disabling radicular arm pain.
- Patients were assigned to either anterior cervical discectomy and fusion or a nonsurgical approach (physician and physical therapy support).
- The primary outcome measure was the Neck Disability Index (NDI) at 12 months.
Main Results:
- In the disc herniation trial, surgical treatment showed a statistically significant improvement in NDI scores at 12 months (mean difference 7.4, P=0.01).
- In the spondylosis trial, no significant difference in NDI scores was observed between surgical and nonsurgical groups (mean difference 2.3, P=0.52).
- Higher crossover rates to surgery were observed in the spondylosis nonsurgical group.
Conclusions:
- Surgical intervention is more effective than nonsurgical treatment for cervical radiculopathy due to disc herniation.
- Surgical versus nonsurgical treatment yields similar outcomes for cervical radiculopathy caused by spondylosis.
- These findings aid in guiding treatment decisions for cervical radiculopathy based on etiology.
