Bacteria-Responsive Drug Delivery System Utilizing Carboxymethyl Cellulose-Functionalized Metal-Organic Framework for
Pingping Yuan1,2, Mengying Zhang1, Sheng Wang1
1Animal-Derived Food Safety Innovation Team, College of Veterinary Medicine, Anhui Agricultural University, Hefei 230036, China.
ACS Biomaterials Science & Engineering
|March 25, 2025
Summary
A novel smart drug delivery system using metal-organic frameworks (MOFs) effectively combats antibiotic resistance. This bacteria-responsive system enhances ceftiofur release, clearing Pseudomonas aeruginosa and improving wound healing in mice.
Area of Science:
- Materials Science
- Biotechnology
- Pharmacology
Background:
- Antibiotic resistance is a growing global health crisis.
- Overuse of antibiotics has accelerated the development of resistant bacterial strains.
- Innovative drug delivery systems are crucial for overcoming antibiotic resistance.
Purpose of the Study:
- To develop a bacteria-responsive drug delivery system using metal-organic frameworks (MOFs).
- To enhance the efficacy of ceftiofur (EFT) against bacterial infections.
- To investigate the potential of MOF-based systems in combating antibiotic resistance.
Main Methods:
- Zeolite imidazole framework 8 (ZIF-8) was used as a carrier for ceftiofur (EFT).
- A smart drug delivery system (CMC-EFT@ZIF-8) was developed, enhanced with carboxymethyl cellulose.
- The system's responsiveness to pH and cellulase was evaluated for EFT release.
- In vitro efficacy against Pseudomonas aeruginosa and in vivo efficacy in a mouse skin wound model were assessed.
Main Results:
- The CMC-EFT@ZIF-8 system demonstrated enhanced EFT release under acidic conditions and in the presence of cellulase.
- The system effectively disrupted bacterial membranes, leading to bacterial death.
- A 99% clearance of Pseudomonas aeruginosa was achieved within 6 hours in vitro.
- Superior efficacy was observed in a mouse skin wound model.
Conclusions:
- The developed smart drug delivery system shows significant potential for treating bacterial infections.
- This MOF-based system represents an advancement in combating antibiotic resistance.
- The bacteria-responsive nature of the system enhances therapeutic outcomes.
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