Related Experiment Video
Updated: May 8, 2025
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Identification and Quantification of Deranged Metabolites in Critically Ill Patients Using NMR-Based Metabolomics
Published on: November 29, 2024
402
Metabolomics and pediatric cardiology
Roberta Pintus1, Angelica Dessì2, Alice Bosco1
1Neonatal Intensive Care Unit, Department of Surgical Sciences, University Hospital of Cagliari, University of Cagliari, Cagliari, Italy.
Minerva Pediatrics
|March 25, 2025
Summary
Metabolomics analysis offers valuable insights into pediatric cardiology, aiding in the prediction of fetal heart abnormalities and surgical outcomes for improved patient care.
Area of Science:
- Pediatric Cardiology
- Metabolomics
- Biomarkers
Background:
- Pediatric heart diseases present unique challenges distinct from adult conditions.
- Understanding the metabolic profile in pediatric cardiac patients is crucial for acute and long-term management.
- Metabolomics offers a powerful tool to explore these metabolic alterations.
Purpose of the Study:
- To review the application of metabolomics in pediatric cardiology research from 2013 to 2024.
- To highlight the potential of metabolomics in diagnosing and managing pediatric heart conditions.
- To identify key areas where metabolomics can advance pediatric cardiac care.
Main Methods:
- Systematic literature review of metabolomics studies in pediatric cardiology.
- Analysis of studies focusing on congenital heart diseases and other pediatric cardiac conditions.
- Evaluation of the reported applications and outcomes of metabolomics in clinical practice.
Main Results:
- Congenital heart diseases are the most frequently studied topic in pediatric cardiology metabolomics.
- Emerging evidence suggests metabolomics can predict fetal cardiac abnormalities.
- Metabolomics shows promise in predicting outcomes for complex pediatric cardiac surgeries.
Conclusions:
- Metabolomics holds significant potential for personalized treatment strategies in pediatric cardiology.
- Further research is needed to fully integrate metabolomics into routine clinical practice for neonates and children with heart diseases.
- This review underscores the expanding role of metabolomics in advancing the field of pediatric cardiovascular medicine.
