Radiofrequency radiation and Alzheimer's disease: harmful and therapeutic implications

Alzheimer's disease (AD) is a neurodegenerative disorder characterized by memory loss and cognitive decline. The relationship between AD and radiofrequency (RF) radiation emitted by wireless devices remains under investigation. The aim of this review is to comprehensively explore the effects of RF radiation on AD by evaluating existing literature. This review used Web of Science, Scopus, and PubMed to find relevant studies on AD and RF radiation. This review evaluates a total of 81 studies, including animal models, human studies, and in vitro experiments, with results summarized in tables for clarity.

Some studies suggest RF aggravates AD by increasing oxidative stress, impairing blood-brain barrier integrity, and promoting amyloid-beta deposition. Conversely, other studies indicate RF may have protective benefits, such as enhancing brain mitochondrial functions and reducing amyloid-beta levels. Understanding the RF-AD relationship, including parameters like frequency and exposure time, is crucial for therapeutic strategies. The studies reviewed highlight RF radiation's dual effects on AD, underscoring the need for a detailed approach. Further studies are required to clarify these effects and inform preventive and therapeutic measures.