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Prenatal Exposure to 3.5 GHz Radiofrequency Radiation and Long-Term Skin Histomorphometry: An 18-Month Experimental
Elif Geleni Dolanbay1, Tugay Mert1, Reyhan Nur Kurtoglu2
1Istanbul Medeniyet University Faculty of Medicine, Department of Histology and Embryology, Istanbul, Türkiye.
Medeniyet Medical Journal
|January 2, 2026
Summary
Prenatal radiofrequency radiation (RFR) exposure did not alter skin structure in aged rats. Long-term skin histomorphometry remained unaffected, suggesting potential protective mechanisms against RFR effects.
Area of Science:
- Environmental Health
- Dermatology
- Toxicology
Background:
- Radiofrequency radiation (RFR) from mobile devices is ubiquitous.
- Long-term health effects of prenatal RFR exposure require further investigation.
- Skin structure and function are crucial for barrier integrity and homeostasis.
Purpose of the Study:
- To assess the long-term effects of in utero exposure to 3.5 GHz RFR on skin histomorphometry.
- To evaluate dermal thickness, adipose tissue, and related parameters in aged rats.
- To determine if prenatal RFR exposure causes lasting changes in skin structure.
Main Methods:
- Pregnant Wistar rats were exposed to 3.5 GHz RFR during gestation.
- Offspring were assessed at 18 months postpartum for skin histomorphometry.
- Skin samples were analyzed for dermal thickness, fat percentage, and other structural parameters.
- Specific absorption rate (SAR) was calculated, and statistical analyses were performed.
Main Results:
- No significant differences were found in dermal thickness between RFR-exposed and sham groups.
- Adipose tissue area, dermal area, and fat percentage showed no statistically significant changes.
- The adipose/dermis ratio was not significantly different between the groups.
- All measured histomorphometric parameters were unaffected by prenatal RFR exposure (p>0.05).
Conclusions:
- Prenatal exposure to 3.5 GHz RFR does not induce significant long-term skin histomorphometric alterations in aged rats.
- The skin's inherent barrier properties and repair mechanisms may mitigate structural damage from RFR.
- Further research is needed to fully understand the long-term implications of RFR exposure on skin health.
