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Updated: Jul 20, 2026

Detection of a Circulating MicroRNA Custom Panel in Patients with Metastatic Colorectal Cancer

Detection of a Circulating MicroRNA Custom Panel in Patients with Metastatic Colorectal Cancer

Published on: March 14, 2019

Associations between Serum Insulin-Like Growth Factor-Related Molecules and Colorectal Cancer Risk by Tumor Location:

Yasushi Adachi, Masanori Nojima^1,2, Yingsong Lin³

¹Division of Gastroenterology, Department of Internal Medicine, Sapporo Shirakaba-dai Hospital, Sapporo, Japan.

|March 25, 2025

Summary

Serum insulin-like growth factor (IGF) binding protein 3 (IGFBP3) and free IGF levels are associated with colorectal cancer (CRC) risk, potentially differing by tumor location. Higher free IGFBP3 and lower free IGF correlate with right-sided CRC risk.

Keywords:

Colorectal cancer Insulin-like growth factor Insulin-like growth factor-binding protein Nested case-control study Right-sided colorectal cancer

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Published on: September 27, 2024

Area of Science:

Endocrinology
Oncology
Molecular Biology

Background:

Insulin-like growth factor (IGF) activity is regulated by IGF-binding proteins (IGFBPs).
Colorectal cancer (CRC) exhibits heterogeneity, with distinct characteristics in left-sided versus right-sided tumors.
Understanding the role of IGF-related molecules in CRC development is crucial.

Purpose of the Study:

To investigate the association between serum levels of IGF-related molecules and the incidence of colorectal cancer (CRC).
To explore potential differences in these associations based on CRC tumor location (left-sided vs. right-sided).

Main Methods:

A case-control study nested within the Japan Collaborative Cohort study.
Serum samples from 39,242 participants were analyzed.
Conditional logistic regression was used to calculate odds ratios (ORs) for CRC incidence related to IGF-related molecules.

Main Results:

No significant associations were found between IGF-related molecules and overall or left-sided CRC risk.
Total and free IGFBP3 levels were associated with an increased risk of right-sided CRC.
Free IGF levels were inversely associated with the risk of right-sided CRC, but positively associated with left-sided CRC risk.

Conclusions:

Serum IGF-related molecules, particularly IGFBP3 and free IGF, are associated with CRC risk.
The association between IGF-related molecules and CRC risk may vary depending on tumor location.