Jove
Visualize
Contact Us
JoVE
x logofacebook logolinkedin logoyoutube logo
ABOUT JoVE
OverviewLeadershipBlogJoVE Help Center
AUTHORS
Publishing ProcessEditorial BoardScope & PoliciesPeer ReviewFAQSubmit
LIBRARIANS
TestimonialsSubscriptionsAccessResourcesLibrary Advisory BoardFAQ
RESEARCH
JoVE JournalMethods CollectionsJoVE Encyclopedia of ExperimentsArchive
EDUCATION
JoVE CoreJoVE BusinessJoVE Science EducationJoVE Lab ManualFaculty Resource CenterFaculty Site
Terms & Conditions of Use
Privacy Policy
Policies

Related Concept Videos

lncRNA - Long Non-coding RNAs02:39

lncRNA - Long Non-coding RNAs

8.4K
In humans, more than 80% of the genome gets transcribed. However, only around 2% of the genome codes for proteins. The remaining part produces non-coding RNAs which includes ribosomal RNAs, transfer RNAs, telomerase RNAs, and regulatory RNAs, among other types. A large number of regulatory non-coding RNAs have been classified into two groups depending upon their length – small non-coding RNAs, such as microRNA, which are less than 200 nucleotides in length, and long non-coding RNA...
8.4K
Bipolar Disorder01:30

Bipolar Disorder

41
Bipolar disorder is a chronic mental health condition marked by significant mood fluctuations, including episodes of mania and depression. Elevated energy levels, heightened mood or irritability, impulsive behavior, reduced sleep needs, rapid speech, racing thoughts, inflated self-esteem, and distractibility characterize mania. Individuals with bipolar disorder often alternate between depressive and manic states, with periods of emotional stability lasting an average of six months to a year.
41
Mania and Antimanic Drugs: Overview01:24

Mania and Antimanic Drugs: Overview

106
Mania, a psychological condition characterized by elevated mood, increased energy, and reduced sleep need, is part of the bipolar disorder cycle. The exact cause of mania isn't entirely known, but it is thought to be a combination of genetic, environmental, and neurological factors. Bipolar disorder involves alternating manic and depressive episodes. Mood stabilizers like lithium, antipsychotics, and anticonvulsants help manage these episodes. Lithium carbonate is particularly effective as...
106
Types of RNA01:20

Types of RNA

5.5K
Three main types of RNA are involved in protein synthesis: messenger RNA (mRNA), transfer RNA (tRNA), and ribosomal RNA (rRNA). These RNAs perform diverse functions and can be broadly classified as protein-coding or non-coding RNA. Non-coding RNAs play important roles in regulating gene expression in response to developmental and environmental changes. Non-coding RNAs in prokaryotes can be manipulated to develop more effective antibacterial drugs for human or animal use.
RNA Performs Diverse...
5.5K
Non-LTR Retrotransposons03:18

Non-LTR Retrotransposons

11.3K
As the name suggests, non-LTR retrotransposons lack the long terminal repeats characteristic of the LTR retrotransposons. Additionally, both LTR and non-LTR retrotransposons use distinct mechanisms of mobilization. Non-LTR retrotransposons are further divided into two classes - Long interspersed nuclear elements (LINEs) and short interspersed nuclear elements (SINEs), both of which occur abundantly in most mammals, including humans. Some of the active non-LTR retrotransposons in humans are L1...
11.3K
Alternative RNA Splicing02:18

Alternative RNA Splicing

20.9K
Alternative RNA splicing is the regulated splicing of exons and introns to produce different mature mRNAs from a single pre-mRNA. Unlike in constitutive splicing where a single gene produces a single type of mRNA, alternative splicing allows an organism to produce multiple proteins from a single gene and plays an important role in protein diversity.
There are five types of alternative RNA splicing that vary in the ways the pre-mRNA segments are removed or retained in the mature mRNA. The first...
20.9K

You might also read

Related Articles

Articles linked to this work by shared authors, journal, and citation graph.

Sort by
Same author

Nutraceuticals: A strategy to mitigate neurotoxicity.

Advances in neurotoxicology·2026
Same author

Geriatric nutritional risk index predicts all-cause mortality in patients with heart failure: an updated systematic review and meta-analysis.

American journal of cardiovascular disease·2026
Same author

Neurochemical biomarkers in major depressive disorder.

Clinica chimica acta; international journal of clinical chemistry·2026
Same author

Cytotoxicity and Coagulation Effects of Methanolic Extracts of <i>Punica granatum, Quercus infectoria, and Achillea millefolium</i>: an in vitro Study.

Journal of experimental pharmacology·2026
Same author

Nanoparticle-mediated radiosensitization in colorectal cancer radiation therapy: A narrative review on mechanisms, clinical translation, and future perspectives.

Applied radiation and isotopes : including data, instrumentation and methods for use in agriculture, industry and medicine·2026
Same author

Nutritional Management of Schizophrenia: Gut-Brain Axis Mechanisms and Dietary Interventions.

Molecular neurobiology·2026

Related Experiment Video

Updated: May 20, 2025

RNA Pull-down Procedure to Identify RNA Targets of a Long Non-coding RNA
09:36

RNA Pull-down Procedure to Identify RNA Targets of a Long Non-coding RNA

Published on: April 10, 2018

25.1K

Long non-coding RNAs in bipolar disorder.

Seyyed Navid Mousavinejad1, Felora Ferdosi2, Siamand Abdolghaderi3

  • 1Department of Clinical Biochemistry, School of Medicine, Shahid Beheshti University of Medical Sciences, Tehran, Iran.

Clinica Chimica Acta; International Journal of Clinical Chemistry
|March 25, 2025
PubMed
Summary

Long noncoding RNAs (lncRNAs) show promise as biomarkers for bipolar disorder, helping differentiate it from other mood disorders. These molecules may also offer new therapeutic targets for drug-resistant cases.

Keywords:
BiomarkersBipolar disorderDepressionManiaNoncoding RNAslncRNAs

More Related Videos

Olfactory Neurons Obtained through Nasal Biopsy Combined with Laser-Capture Microdissection: A Potential Approach to Study Treatment Response in Mental Disorders
08:33

Olfactory Neurons Obtained through Nasal Biopsy Combined with Laser-Capture Microdissection: A Potential Approach to Study Treatment Response in Mental Disorders

Published on: December 4, 2014

9.7K
Chromatin Isolation by RNA Purification ChIRP
11:09

Chromatin Isolation by RNA Purification ChIRP

Published on: March 25, 2012

86.0K

Related Experiment Videos

Last Updated: May 20, 2025

RNA Pull-down Procedure to Identify RNA Targets of a Long Non-coding RNA
09:36

RNA Pull-down Procedure to Identify RNA Targets of a Long Non-coding RNA

Published on: April 10, 2018

25.1K
Olfactory Neurons Obtained through Nasal Biopsy Combined with Laser-Capture Microdissection: A Potential Approach to Study Treatment Response in Mental Disorders
08:33

Olfactory Neurons Obtained through Nasal Biopsy Combined with Laser-Capture Microdissection: A Potential Approach to Study Treatment Response in Mental Disorders

Published on: December 4, 2014

9.7K
Chromatin Isolation by RNA Purification ChIRP
11:09

Chromatin Isolation by RNA Purification ChIRP

Published on: March 25, 2012

86.0K

Area of Science:

  • Genetics
  • Molecular Biology
  • Psychiatry

Background:

  • Bipolar disorder involves alternating manic and depressive episodes, with significant treatment resistance in about 30% of patients.
  • Current diagnostic methods may not fully distinguish bipolar disorder from other mood disorders.
  • Long noncoding RNAs (lncRNAs) are emerging as critical regulators of gene expression.

Purpose of the Study:

  • To review the diagnostic and therapeutic potential of lncRNAs in bipolar disorder.
  • To explore lncRNAs as biomarkers for improved diagnostic accuracy.
  • To identify lncRNAs as potential targets for novel treatment strategies.

Main Methods:

  • Literature review of studies investigating lncRNAs in bipolar disorder.
  • Analysis of identified lncRNAs and their regulatory mechanisms.
  • Examination of lncRNA expression patterns in bipolar disorder patients.

Main Results:

  • Several lncRNAs, including GAS5, FOXD3-AS1, lincRNA-p21, lincRNA-ROR, and lincRNA-PINT, are linked to bipolar disorder.
  • Downregulation of specific lncRNAs (e.g., GAS5, FOXD3-AS1) observed in bipolar disorder patients.
  • LncRNAs demonstrate potential as diagnostic biomarkers and therapeutic targets.

Conclusions:

  • LncRNAs hold significant promise as diagnostic biomarkers for bipolar disorder.
  • Targeting lncRNAs may lead to innovative therapeutic approaches for bipolar disorder.
  • Further research into lncRNAs can enhance personalized treatment strategies for bipolar disorder.