Related Experiment Video
Updated: May 20, 2025
Anterior Segment Organ Culture Platform for Tracking Open Globe Injuries and Therapeutic Performance
Published on: August 25, 2021
Perfluorocarbon liquid as a short-term tamponade for managing severe open globe injuries
Liang Li1, Xinghong Sun1, Mengru Su1
1Department of Ophthalmology, Nanjing Drum Tower Hospital, Affiliated Hospital of Medical School, Nanjing University, No.321 Zhongshan Rd, Nanjing, 210008, Jiangsu, China.
Purpose:
To explore the use of perfluorocarbon liquids (PFCLs) as a short-term tamponade in a staged vitrectomy approach for managing severe open globe injuries (OGIs).
Methods:
This retrospective, interventional case series included patients undergoing 23-gauge pars plana vitrectomy with PFCL tamponade for 7-14 days (mean 11.2 ± 3.36 days), followed by secondary vitrectomy and silicone oil exchange. Key outcome measures included retinal and choroidal reattachment rates, best-corrected visual acuity (BCVA), intraocular pressure (IOP), and postoperative complications. Statistical analyses were performed using McNemar's test and Student's t-test.
Results:
Five eyes from five patients (mean age 55.6 ± 10.12 years; male to female ratio 4:1) were included, with a mean follow-up of 8.4 ± 4.9 months. All patients sustained zone II and III globe ruptures secondary to blunt trauma, with baseline visual acuity ranging from light perception (LP) to no light perception (NLP). Intraoperative findings included total hyphema, funnel retinal detachment, traumatic choroidal rupture (TCR), suprachoroidal hemorrhage (SCH) and extensive intraocular hemorrhage (EIH). Following PFCL removal, SCH exhibited full or partial resolution, and the posterior retina remained attached in all cases. All eyes were salvaged, and visual acuity improved to hand motion (HM) on postoperative day 1, maintaining stability throughout follow-up (P = 0.03682). No significant IOP changes were observed postoperatively (preoperative: 9.66 ± 2.38 mmHg; postoperative: 9.48 ± 3.31 mmHg, P = 0.9063). Retinal and choroidal attachment were maintained during follow-up, with no cases of phthisis bulbi, endophthalmitis, recurrent hyphema, or ocular hypertension. One patient developed corneal degeneration three months postoperatively.
Conclusions:
Short-term PFCL tamponade in a staged vitrectomy may facilitates retinal and choroidal stabilization while minimizing complications, offering a viable alternative for managing severe OGIs.
