Association Between Poor Lifestyle Habits and Cutaneous Melanoma Risk: A Mendelian Randomization Study

There is still no consensus on the risk factors of cutaneous melanoma, and the causal relationship between poor lifestyle habits (including undersleeping, smoking, alcohol consumption and sedentary behaviour) and cutaneous melanoma remains uncertain.

We investigated the causal effect of poor lifestyle habits on cutaneous melanoma through the Two-sample Mendelian randomization (MR). MR analysis was performed by using the genome-wide association studies (GWAS) statistics. Single-nucleotide polymorphisms (SNPs) robustly associated with undersleeping, smoking, alcohol consumption and sedentary behaviour were used as instrumental variables, we performed five MR approaches, including inverse variance weighted (IVW), weighted median, simple mode, MR-Egger and weighted mode.

The causal relationship between undersleeping and cutaneous melanoma was discovered in IVW (OR = 1.018, 95% CI = 1.002-1.033, P = 0.025). However, the causal association between smoking, alcohol consumption, sedentary behaviour and cutaneous melanoma have not been found in all MR approaches.

The MR analysis indicated that undersleeping is causally associated with the risk of cutaneous melanoma.