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Simultaneous Detection of Neural Activity and Temperature in Photothermal Neural Stimulation.
Duhee Kim1, Jee Woong Lee1,2, Seoyoung Kang3
1Department of Electrical Engineering and Computer Science, Daegu Gyeongbuk Institute of Science and Technology (DGIST), Daegu, 42988, Republic of Korea.
Advanced Science (Weinheim, Baden-Wurttemberg, Germany)
|March 26, 2025
Summary
Researchers developed ultrasensitive temperature sensors to precisely measure cell membrane changes during photothermal neuromodulation. This technology offers new insights into treating brain diseases by understanding optical stimulation
Area of Science:
- Neuroscience
- Biomedical Engineering
- Materials Science
Background:
- Photothermal neuromodulation offers a non-electrical approach for brain disease treatment by utilizing optically induced temperature changes.
- Current limitations include difficulties in precisely measuring cellular temperature changes and recording neural activity during optical stimulation.
- Accurate measurement of temperature at the cell interface is crucial for understanding photothermal neuromodulation mechanisms and cellular responses.
Purpose of the Study:
- To develop ultrasensitive cell membrane interface temperature sensors integrated with low-noise electrical recording capabilities.
- To overcome limitations in measuring temperature changes and electrical signals during optical stimulation of neural cells.
- To provide insights into the mechanism of photothermal neuromodulation and its effects on cellular behavior for neurological disorder treatments.
Main Methods:
- Fabrication of transparent resistive temperature detectors using a 10 nm ultrathin gold (Au) film via polyelectrolyte seed layer-induced thermal evaporation.
- Development of a multifunctional system integrating ultrasensitive temperature sensing and low-noise electrical recording capabilities.
- Utilizing the system to measure temperature changes and neural spike activities in hippocampal neurons during photothermal stimulation.
Main Results:
- The developed ultrathin Au film temperature sensors achieved precise temperature measurement and control with minimal light interference and self-heating.
- A transparent electrode made of the same ultrathin Au layer enabled low-noise electrical recordings of neural signals during photothermal stimulation.
- An average temperature increase of 2.34 °C at neuronal cell surfaces resulted in over 95% suppression of hippocampal neural spike activities.
Conclusions:
- The developed multifunctional system provides a novel approach for high-precision temperature sensing and electrical recording without light interference.
- This technology offers unprecedented insights into the mechanisms of photothermal neuromodulation and its impact on neuronal activity.
- The findings pave the way for advanced, targeted treatments of neurological disorders using photothermal neuromodulation.
