Novel Soft Dosage Forms for Paediatric Applications: Can We 3D-Print Them or Not?

Area of Science:

• Pharmaceutical Sciences
• Materials Science
• Biomedical Engineering

Background:

• Novel dosage forms, including gels, are crucial for paediatric treatment, demanding flexible dosing and patient-friendly delivery.
• 3D printing technology is emerging as a key tool for personalized formulation development in pharmaceuticals.

Purpose of the Study:

• To review the current possibilities of 3D printing for paediatric dosage forms.
• To compare gel-like and non-gel-formulated dosage forms created using 3D printing.
• To discuss crucial aspects of developing these advanced dosage forms.

Main Methods:

• Review of existing literature on 3D printing techniques for soft dosage forms.
• Analysis of semi-solid extrusion and other additive manufacturing methods for gel printing.
• Exploration of formulation strategies for 3D printed paediatric medicines.

Main Results:

• 3D printing, particularly semi-solid extrusion, enables flexible dosing and design customization for soft dosage forms.
• Gel-based gummies and hydrogels are promising candidates for 3D fabrication in paediatric medicine.
• Chewing gums and other soft formulations require further evaluation for 3D printing applications.

Conclusions:

• 3D printing presents a viable solution for creating tailored medicines for paediatric patients.
• Further research is needed to advance the development and clinical application of 3D printed soft dosage forms.
• The technology holds significant potential for personalized drug delivery in paediatrics.