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The Therapeutic Potential of Orange Juice in Cardiac Remodeling: A Metabolomics Approach
Priscila Portugal Dos Santos1, Anderson Seiji Soares Fujimori1, Bertha Furlan Polegato1
1Internal Medicine Department, Botucatu Medical School, Sao Paulo State University (UNESP), Botucatu 18618-687, Brazil.
Insights
Orange juice consumption may help reduce cardiac remodeling, a key factor in heart failure. Its metabolites improve metabolic health and gut bacteria, offering potential dietary support for cardiovascular disease management.
Area of Science:
- Cardiovascular Medicine
- Nutritional Science
- Metabolic Research
Background:
- Cardiac remodeling is a primary driver of cardiovascular disease mortality.
- Effective therapies are needed to attenuate cardiac remodeling and reduce heart failure progression.
- Dietary interventions with cardioprotective foods present a promising adjuvant strategy.
Purpose of the Study:
- To explore the potential of orange juice (OJ) as a dietary factor in modulating cardiac remodeling.
- To investigate the metabolic pathways and metabolites influenced by OJ consumption relevant to cardiovascular health.
- To assess the impact of OJ on metabolic syndrome components and gut microbiota.
Main Methods:
- Review of current literature on OJ metabolites and their effects on cellular and metabolic processes.
- Analysis of how OJ modulates key pathways including phospholipid metabolism, energy metabolism, and gut microbiota.
- Correlation of OJ-induced metabolic changes with improvements in insulin resistance, dyslipidemia, and metabolic syndrome.
Main Results:
- OJ intake significantly modulates phospholipids, energy metabolism, endocannabinoid signaling, amino acids, and gut microbiota diversity.
- Specific effects include modulation of phosphatidylethanolamine metabolism and activation of PPARα/PPARγ receptors, enhancing energy metabolism and reducing oxidative stress.
- OJ consumption improved insulin resistance, dyslipidemia, and metabolic syndrome, with increased beneficial gut bacteria.
Conclusions:
- Orange juice acts as a metabolic modulator with potential cardioprotective effects.
- Metabolites and pathways influenced by OJ may attenuate cardiac remodeling.
- Dietary OJ shows promise as an adjuvant therapy for cardiovascular diseases by improving metabolic health and gut microbiota.
Abstract:
Cardiovascular diseases are a leading cause of death worldwide, and the process of cardiac remodeling lies at the core of most of these diseases. Sustained cardiac remodeling almost unavoidably ends in progressive muscle dysfunction, heart failure, and ultimately death. Therefore, in order to attenuate cardiac remodeling and reduce mortality, different therapies have been used, but it is important to identify adjuvant factors that can help to modulate this process. One of these factors is the inclusion of affordable foods in the diet with potential cardioprotective properties. Orange juice intake has been associated with several beneficial metabolic changes, which may influence cardiac remodeling induced by cardiovascular diseases. Current opinion highlights how the metabolites and metabolic pathways modulated by orange juice consumption could potentially attenuate cardiac remodeling. It was observed that orange juice intake significantly modulates phospholipids, energy metabolism, endocannabinoid signaling, amino acids, and gut microbiota diversity, improving insulin resistance, dyslipidemia, and metabolic syndrome. Specifically, modulation of phosphatidylethanolamine (PE) metabolism and activation of PPARα and PPARγ receptors, associated with improved energy metabolism, mitochondrial function, and oxidative stress, showed protective effects on the heart. Furthermore, orange juice intake positively impacted gut microbiota diversity and led to an increase in beneficial bacterial populations, correlated with improved metabolic syndrome. These findings suggest that orange juice may act as a metabolic modulator, with potential therapeutic implications for cardiac remodeling associated with cardiovascular diseases.
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