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Expression, Purification, Crystallization, and Enzyme Assays of Fumarylacetoacetate Hydrolase Domain-Containing Proteins
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Metronidazole Activation by a Deeply Entangled Dimeric Malic Enzyme in Entamoeba histolytica

Arindam Chakrabarty1, Debajyoti Dutta2, Mithu Baidya3

  • 1Department of Bioscience and Biotechnology, Indian Institute of Technology Kharagpur, Kharagpur 721302, India.

Pathogens (Basel, Switzerland)
|March 26, 2025
PubMed
Summary

Researchers discovered a new way the parasite Entamoeba histolytica activates the drug metronidazole using a malic enzyme. This enzyme

Keywords:
Entamoeba histolyticacrystal structureentangled proteinknotmetronidazoleprotozoa

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