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Mucoepidermoid Carcinoma Associated with an Intercalated Duct Lesion: Precursor or Coincidence?
Joshua S Goldfaden1, Seungwon Kim2, Raja R Seethala2,3
1Oral and Maxillofacial Pathology Resident, Department of Diagnostic Sciences, School of Dental Medicine, University of Pittsburgh, G-132 Salk Hall, 3501 Terrace Street, Pittsburgh, PA, 15261, USA. jsg114@pitt.edu.
Background:
Mucoepidermoid carcinoma (MEC) typically occurs in isolation. We report an unusual case of MEC coexisting with an intercalated duct lesion (IDL), both harboring MAML2 rearrangements.
Case Presentation:
An 82-year-old male with a left parotid mass underwent superficial parotidectomy.
Methods:
Microscopic examination of immunohistochemical stains and fluorescence in situ hybridization (FISH) studies were performed.
Results:
The parotid demonstrated an intermediate grade MEC and an adjacent IDL with the typical abluminal ΔNp63 (p40) and ductal SOX-10 immunopositivity, but absent LEF-1 and nuclear β-catenin staining. FISH confirmed MAML2 rearrangements in both lesions.
Conclusion:
This case expands the spectrum of IDL-associated tumors and suggests IDLs may serve as MEC precursors.
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