Related Experiment Video
Updated: May 20, 2025

Author Spotlight: Overcoming Challenges in Drosophila Sleep Measurement Using DAM System
Published on: October 20, 2023
Melatonin Interventions in Autism Spectrum Disorder: Sleep Regulation, Behavioral Outcomes, and Challenges Across the
Geir Bjørklund1, Oleksandra Oleshchuk2, Yana Ivankiv2
1Council for Nutritional and Environmental Medicine (CONEM), Toften 24, 8610, Mo I Rana, Norway. bjorklund@conem.org.
Abstract:
Autism spectrum disorder (ASD) poses complex challenges affecting social interaction, communication, and behavior, necessitating comprehensive and tailored interventions. Sleep disturbances, prevalent in up to 80% of individuals with ASD, significantly impact well-being. Central to circadian rhythms, melatonin emerges as a promising intervention, primarily recognized for its role in sleep regulation. This review explores melatonin's multifactor impact on ASD, covering sleep regulation, behavioral outcomes, neuroprotection, and potential synergies with other therapies. Melatonin exhibits promise in ameliorating sleep disturbances and enhancing overall well-being, with implications for social behaviors, communication, and repetitive behaviors. Its antioxidant and anti-inflammatory properties further suggest potential neuroprotective benefits. Future research directions focus on mechanistic insights, individualized medicine, and real-world effectiveness. As melatonin's versatile role unfolds, it stands as a valuable component in the personalized care of individuals navigating the complexities of ASD.
Related Concept Videos
Management of Insomnia
Autism Spectrum Disorder
These core symptoms manifest differently among individuals, ranging from mild to severe. The disorder's complexity extends beyond its clinical presentation, encompassing a diverse range of biological, cognitive, and sociocultural influences.
Insomnia
Multiple factors contribute...
Modeling in Therapy
Participant Modeling
Participant modeling involves therapists demonstrating calm and effective behaviors in...
Sedatives and Hypnotics Drugs: Miscellaneous Agents
Melatonin congeners like ramelteon (Rozerem) and tasimelteon (Hetlioz) selectively bind to melatonin receptors (MT1 and MT2) and thus mimic the actions of melatonin, a hormone that regulates sleep-wake cycles. Tasimelteon is primarily used for non-24-hour sleep-wake disorder, common in blind patients. They are also used to treat conditions like insomnia...
Narcolepsy

