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Updated: May 20, 2025

Signal Attenuation as a Rat Model of Obsessive Compulsive Disorder
Published on: January 9, 2015
Editorial: Meta-Analysis of Individual Participant Data From Trials of Selective Serotonin Reuptake Inhibitors for
1University of Minnesota Medical School, Masonic Institute for the Developing Brain, Minneapolis, Minnesota.
None:
Pediatric obsessive-compulsive disorder (OCD) is a common (2% prevalence) and potentially debilitating condition.1 Early identification and intervention are critical because they may improve outcomes for children and adolescents with OCD and prevent long-term morbidity. The individual participant data (IPD) meta-analysis by Cohen and colleagues2 explores the efficacy of short-term trials of selective serotonin reuptake inhibitors (SSRIs) compared to placebo for treating children and adolescents with OCD. It also investigates the moderating effects of baseline patient variables on treatment outcome.
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