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Updated: May 20, 2025

Cell Squeezing as a Robust, Microfluidic Intracellular Delivery Platform
Published on: November 7, 2013
The delivery carriers and applications for Xiaobojian
Shiyu Huang1,2, Gangliang Huang3
1Key Laboratory of Carbohydrate Science and Engineering, Chongqing Key Laboratory of Inorganic Functional Materials, Chongqing Normal University, Chongqing, 401331, China.
Abstract:
Berberine, also known as Xiaobojian (XBJ), is a quaternary ammonium alkaloid isolated from the traditional Chinese medicine Coptis chinensis, and is the main effective ingredient for antibacterial purpose. This work systematically reviewed recent researches on XBJ in the whole range of delivery technologies. Compared with XBJ monomer administration, other forms of drug administration, such as tablets, pellets, XBJ polymer delivery system, lipid delivery system, superdeformed vesicles nanocrystallization or emulsification of XBJ and some special substances, will increase the absorption of XBJ. XBJ can be administered through various carriers, including oral administration and topical application. The importance of XBJ carrier administration is mainly reflected in wide application prospects, various pharmacological effects, and improving drug efficacy.
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