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The delivery carriers and applications for Xiaobojian
Shiyu Huang1,2, Gangliang Huang3
1Key Laboratory of Carbohydrate Science and Engineering, Chongqing Key Laboratory of Inorganic Functional Materials, Chongqing Normal University, Chongqing, 401331, China.
Discover Nano
|March 27, 2025
Summary
Berberine (XBJ) delivery systems enhance its absorption and therapeutic potential. Various carriers, including oral and topical, improve efficacy and expand applications for this traditional Chinese medicine ingredient.
Area of Science:
- Pharmacology
- Drug Delivery Systems
- Traditional Chinese Medicine
Background:
- Berberine (XBJ), a key alkaloid from Coptis chinensis, possesses significant antibacterial properties.
- Traditional administration of XBJ has limitations in bioavailability and efficacy.
Purpose of the Study:
- To systematically review recent advancements in Berberine (XBJ) delivery technologies.
- To highlight the benefits of various XBJ carrier systems over monomer administration.
Main Methods:
- Systematic literature review of XBJ delivery technologies.
- Analysis of different drug administration forms including tablets, pellets, polymer systems, lipid systems, and nanocrystallization/emulsification.
Main Results:
- Various delivery systems (tablets, pellets, polymer, lipid, vesicles, nanocrystallization, emulsification) significantly increase XBJ absorption compared to monomer administration.
- XBJ can be effectively delivered via oral and topical routes using different carriers.
Conclusions:
- Carrier-mediated administration of Berberine (XBJ) offers wide application prospects.
- Advanced delivery systems are crucial for enhancing XBJ's pharmacological effects and overall drug efficacy.
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