Jove
Visualize
Contact Us
JoVE
x logofacebook logolinkedin logoyoutube logo
ABOUT JoVE
OverviewLeadershipBlogJoVE Help Center
AUTHORS
Publishing ProcessEditorial BoardScope & PoliciesPeer ReviewFAQSubmit
LIBRARIANS
TestimonialsSubscriptionsAccessResourcesLibrary Advisory BoardFAQ
RESEARCH
JoVE JournalMethods CollectionsJoVE Encyclopedia of ExperimentsArchive
EDUCATION
JoVE CoreJoVE BusinessJoVE Science EducationJoVE Lab ManualFaculty Resource CenterFaculty Site
Terms & Conditions of Use
Privacy Policy
Policies

Related Concept Videos

lncRNA - Long Non-coding RNAs02:39

lncRNA - Long Non-coding RNAs

8.4K
In humans, more than 80% of the genome gets transcribed. However, only around 2% of the genome codes for proteins. The remaining part produces non-coding RNAs which includes ribosomal RNAs, transfer RNAs, telomerase RNAs, and regulatory RNAs, among other types. A large number of regulatory non-coding RNAs have been classified into two groups depending upon their length – small non-coding RNAs, such as microRNA, which are less than 200 nucleotides in length, and long non-coding RNA...
8.4K
Gap Junctions01:27

Gap Junctions

7.9K
The cytoplasm of adjacent animal cells can exchange small molecules, ions, and secondary messengers via the communication channels which form the gap junctions. These junctions comprise a few hundred to thousands of molecular channels, each made of two halves, called the connexon hemichannel. A connexon is a hexamer of six transmembrane connexin proteins, which assemble radially, thus forming a pore or channel in the center. One connexon hemichannel docks with a corresponding connexon on the...
7.9K
RNA Splicing01:32

RNA Splicing

55.8K
Splicing is the process by which eukaryotic RNA is edited before its translation into protein. The RNA strand transcribed from eukaryotic DNA is called the primary transcript. The primary transcripts that become mRNAs are called precursor messenger RNAs (pre-mRNAs). Eukaryotic pre-mRNA contains alternating sequences of exons and introns. Exons are nucleotide sequences that code for proteins, whereas introns are the non-coding regions. In RNA splicing, introns are removed and exons are bonded...
55.8K
MicroRNAs01:22

MicroRNAs

3.0K
MicroRNA (miRNA) are short, regulatory RNA transcribed from introns (non-coding regions of a gene) or intergenic regions (stretches of DNA present between genes). Several processing steps are required to form biologically active, mature miRNA. The initial transcript, called primary miRNA (pri-mRNA), base-pairs with itself, forming a stem-loop structure. Within the nucleus, an endonuclease enzyme, called Drosha, shortens the stem-loop structure into hairpin-shaped pre-miRNA. After the pre-miRNA...
3.0K
Non-Canonical Wnt Signaling Pathways01:41

Non-Canonical Wnt Signaling Pathways

7.2K
Wnt is a zygotic effect gene that is expressed during very early embryonic development. It regulates various processes in animals starting from early development through the adult stage, such as organogenesis in the embryo and maintenance of neuronal and blood stem cells. Wnt proteins can induce a wide variety of intracellular pathways depending upon the specific abilities of different Wnt ligands to form a complex with shared and cognate receptors in the presence of different co-receptors. The...
7.2K
Protein Networks02:26

Protein Networks

3.9K
An organism can have thousands of different proteins, and these proteins must cooperate to ensure the health of an organism. Proteins bind to other proteins and form complexes to carry out their functions. Many proteins interact with multiple other proteins creating a complex network of protein interactions.
These interactions can be represented through maps depicting protein-protein interaction networks, represented as nodes and edges. Nodes are circles that are representative of a protein,...
3.9K

You might also read

Related Articles

Articles linked to this work by shared authors, journal, and citation graph.

Sort by
Same author

Amine-Functionalized and Gold-Decorated Amine-Functionalized TiO<sub>2</sub> Nanoparticles Modulate Breast Cancer Cell Viability.

International journal of molecular sciences·2026
Same author

Long-term exposure to N-(phosphonomethyl)glycine is associated with cancer stem cell-like properties in hormone-responsive breast cancer cells.

Toxicology·2026
Same author

Glyphosate-Based Herbicides and Their Potential Impact on the Microbiota of Social Bees.

Toxics·2025
Same author

Oncolytic Viruses as a Novel Therapeutic Approach for Colorectal Cancer: Mechanisms, Current Advances, and Future Directions.

Cancers·2025
Same author

Tumor hypoxia shapes natural killer cell anticancer activities.

Journal of molecular medicine (Berlin, Germany)·2025
Same author

<i>Porphyromonas gingivalis</i> and Human Cytomegalovirus Co-Infection: A Potential Link Between Periodontal Disease and Oral Cancer Development.

Cancers·2025

Related Experiment Video

Updated: May 20, 2025

Analysis of the Gap Junction-dependent Transfer of miRNA with 3D-FRAP Microscopy
06:26

Analysis of the Gap Junction-dependent Transfer of miRNA with 3D-FRAP Microscopy

Published on: June 19, 2017

8.8K

Molecular Interplay Between Non-Coding RNAs and Connexins and Its Possible Role in Cancer.

Pablo Pérez-Moreno1, Juan P Muñoz2, Mauricio A Retamal1

  • 1Programa de Comunicación Celular en Cáncer, Instituto de Ciencias e Innovación en Medicina (ICIM), Facultad de Medicina Clínica Alemana, Universidad del Desarrollo, Santiago 7780272, Chile.

International Journal of Molecular Sciences
|March 27, 2025
PubMed
Summary

Non-coding RNAs (ncRNAs) and connexins (Cxs) are crucial in cell processes. Their dysregulation in cancer promotes aggressive traits, suggesting potential as biomarkers.

Keywords:
cancerconnexinsnon-coding RNAs

More Related Videos

CRISPR Gene Editing Tool for MicroRNA Cluster Network Analysis
10:40

CRISPR Gene Editing Tool for MicroRNA Cluster Network Analysis

Published on: April 25, 2022

2.3K
Analysis of Protein-protein Interactions and Co-localization Between Components of Gap, Tight, and Adherens Junctions in Murine Mammary Glands
11:31

Analysis of Protein-protein Interactions and Co-localization Between Components of Gap, Tight, and Adherens Junctions in Murine Mammary Glands

Published on: May 30, 2017

10.0K

Related Experiment Videos

Last Updated: May 20, 2025

Analysis of the Gap Junction-dependent Transfer of miRNA with 3D-FRAP Microscopy
06:26

Analysis of the Gap Junction-dependent Transfer of miRNA with 3D-FRAP Microscopy

Published on: June 19, 2017

8.8K
CRISPR Gene Editing Tool for MicroRNA Cluster Network Analysis
10:40

CRISPR Gene Editing Tool for MicroRNA Cluster Network Analysis

Published on: April 25, 2022

2.3K
Analysis of Protein-protein Interactions and Co-localization Between Components of Gap, Tight, and Adherens Junctions in Murine Mammary Glands
11:31

Analysis of Protein-protein Interactions and Co-localization Between Components of Gap, Tight, and Adherens Junctions in Murine Mammary Glands

Published on: May 30, 2017

10.0K

Area of Science:

  • Molecular Biology
  • Cancer Biology
  • Biochemistry

Background:

  • Non-coding RNAs (ncRNAs) regulate cellular processes like proliferation and differentiation.
  • Connexins (Cxs) are transmembrane proteins essential for intercellular communication.
  • Dysregulation of ncRNAs and Cxs is observed in cancer, correlating with increased aggressiveness.

Purpose of the Study:

  • To review the interplay between ncRNAs and Cxs in cancer.
  • To analyze their influence on cancer cell aggressiveness and patient outcomes.
  • To explore their potential as clinical biomarkers for cancer diagnosis, prognosis, and therapy.

Main Methods:

  • Literature review of studies investigating ncRNA-Cx interactions in cancer.
  • Analysis of how these interactions affect cancer cell phenotypes (proliferation, invasion).
  • Evaluation of clinicopathological data related to ncRNA and Cx expression in cancer patients.

Main Results:

  • ncRNAs and Cxs exhibit complex interactions that contribute to cancer progression.
  • Altered expression/function of ncRNAs and Cxs enhances cancer cell proliferation and invasion.
  • These molecules show potential for predicting patient prognosis and response to treatment.

Conclusions:

  • The ncRNA-Cx axis is a significant factor in cancer aggressiveness.
  • Targeting ncRNAs and Cxs may offer novel therapeutic strategies.
  • ncRNAs and Cxs hold promise as biomarkers for improved cancer management.