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Related Experiment Video

Updated: Jun 27, 2026

Synthesis of Aptamer-PEI-g-PEG Modified Gold Nanoparticles Loaded with Doxorubicin for Targeted Drug Delivery
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Amine-Functionalized and Gold-Decorated Amine-Functionalized TiO2 Nanoparticles Modulate Breast Cancer Cell

Juan P Muñoz1, Kiamara Muñoz-Jaime2, Diego Soto-Jiménez1

  • 1Laboratorio de Bioquímica, Departamento de Química, Facultad de Ciencias, Universidad de Tarapacá, Arica 1000007, Chile.

International Journal of Molecular Sciences
|June 26, 2026
PubMed
Summary

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Correction: Caguana et al. Metal Nanoparticles Obtained by Green Hydrothermal and Solvothermal Synthesis: Characterization, Biopolymer Incorporation, and Antifungal Evaluation Against <i>Pseudocercospora fijiensis</i>. <i>Nanomaterials</i> 2025, <i>15</i>, 379.

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Nanomaterials (Basel, Switzerland)·2025

Surface engineering of titanium dioxide nanoparticles (TiO2NPs) with amines and gold significantly impacts breast cancer cell viability. Surface modification, not the TiO2 core, dictates cellular response, suggesting potential for new adjuvant cancer therapies.

Area of Science:

  • Nanomaterials Science
  • Biomedical Engineering
  • Cancer Research

Background:

  • Surface engineering of titanium dioxide nanoparticles (TiO2NPs) is crucial for controlling their biological interactions.
  • TiO2NPs hold promise for localized or adjuvant cancer treatment strategies targeting residual cancer cells.

Purpose of the Study:

  • To investigate how amine functionalization and gold decoration of TiO2NPs affect breast cancer cell lines (MCF7 and MDA-MB-231).
  • To determine if surface modification alters the cytotoxic effects of TiO2NPs.

Main Methods:

  • Synthesis of pristine TiO2NPs, amine-functionalized TiO2NPs (TiO2NPs-NH2), and gold-decorated TiO2NPs (Au@TiO2NPs-NH2).
  • Evaluation of cellular effects using MTT assays and Trypan Blue exclusion counting after 24h exposure.
Keywords:
Au@TiO2NPs-NH2TiO2 nanoparticlesTiO2NPs-NH2breast cancer cellssurface modification

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  • Characterization of physicochemical and optical properties of the synthesized nanomaterials.

    • Main Results:

    • Surface modification altered physicochemical and optical properties while preserving the anatase TiO2 framework.
    • Pristine TiO2NPs showed minimal impact on cell viability.
    • TiO2NPs-NH2 and Au@TiO2NPs-NH2 reduced cancer cell viability concentration-dependently and cell line-dependently.
    • Cytotoxicity was more pronounced in MTT assays than Trypan Blue exclusion, indicating metabolic changes prior to membrane damage.

    Conclusions:

    • Surface modification is the primary driver of cellular response to TiO2NPs, outweighing the effect of the TiO2 core alone.
    • Surface-engineered TiO2NPs show potential as platforms for future adjuvant breast cancer therapies.
    • Further in vitro mechanistic studies are warranted to explore these nanomaterials for cancer treatment.