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Updated: May 20, 2025

Imaging Approaches to Assessments of Toxicological Oxidative Stress Using Genetically-encoded Fluorogenic Sensors
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Imaging Approaches to Assessments of Toxicological Oxidative Stress Using Genetically-encoded Fluorogenic Sensors

Published on: February 7, 2018

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Targeting Oxidative Stress for Disease

Nada Oršolić1, Maja Jazvinšćak Jembrek2,3

  • 1Division of Animal Physiology, Faculty of Science, University of Zagreb, Rooseveltov trg 6, HR-10000 Zagreb, Croatia.

International Journal of Molecular Sciences
|March 27, 2025
PubMed

Insights

Oxidative stress occurs when reactive oxygen species (ROS) overwhelm the body's antioxidant defenses. This imbalance impacts cellular health and function.

Area of Science:

  • Biochemistry
  • Cell Biology
  • Physiology

Background:

  • Oxidative stress (OS) arises from an imbalance between reactive oxygen species (ROS) production and antioxidant capacity.
  • Excessive ROS can damage cellular components, including lipids, proteins, and nucleic acids.

Discussion:

  • OS is implicated in the pathogenesis of numerous diseases, including neurodegenerative disorders, cardiovascular diseases, and cancer.
  • Understanding the molecular mechanisms underlying OS is crucial for developing therapeutic strategies.

Key Insights:

  • The study investigates the complex interplay between ROS and antioxidant systems.
  • Novel biomarkers for OS detection and monitoring are explored.

Outlook:

  • Further research into targeted antioxidant therapies holds promise for mitigating OS-related damage.
  • Investigating the role of OS in aging and age-related diseases is a key future direction.

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